BDBM50292389 3-epi-fagomine::3-epifagomine::CHEMBL456583
SMILES: OC[C@H]1NCC[C@H](O)[C@@H]1O
InChI Key: InChIKey=YZNNBIPIQWYLDM-NGJCXOISSA-N
Data: 14 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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β-galactosidase (Bos taurus (Bovine)) | BDBM50292389 (3-epi-fagomine | 3-epifagomine | CHEMBL456583) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Concentration that causes 50% inhibition of mammalian cytosolic beta-galactosidase was determined in bovine liver | J Med Chem 37: 3701-6 (1994) BindingDB Entry DOI: 10.7270/Q2ZC83H3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
β-galactosidase (Bos taurus (Bovine)) | BDBM50292389 (3-epi-fagomine | 3-epifagomine | CHEMBL456583) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Tested for competitive inhibition of bovine liver beta-galactosidase | J Med Chem 37: 3701-6 (1994) BindingDB Entry DOI: 10.7270/Q2ZC83H3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat)) | BDBM50292389 (3-epi-fagomine | 3-epifagomine | CHEMBL456583) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of Wistar rat intestinal isomaltase by glucose B-test | J Nat Prod 60: 312-4 (1997) Article DOI: 10.1021/np960646y BindingDB Entry DOI: 10.7270/Q2WQ03TX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucosylceramidase (Bos taurus) | BDBM50292389 (3-epi-fagomine | 3-epifagomine | CHEMBL456583) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama Curated by ChEMBL | Assay Description Inhibition of bovine liver beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate ... | Bioorg Med Chem 19: 3558-68 (2011) Article DOI: 10.1016/j.bmc.2011.04.011 BindingDB Entry DOI: 10.7270/Q2BC3ZWW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
β-galactosidase (Bos taurus (Bovine)) | BDBM50292389 (3-epi-fagomine | 3-epifagomine | CHEMBL456583) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama Curated by ChEMBL | Assay Description Inhibition of bovine liver beta-galactosidase assessed as production of p-nitrophenol by spectrophotometry | Bioorg Med Chem 19: 3558-68 (2011) Article DOI: 10.1016/j.bmc.2011.04.011 BindingDB Entry DOI: 10.7270/Q2BC3ZWW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactase-glycosylceramidase (Rattus norvegicus) | BDBM50292389 (3-epi-fagomine | 3-epifagomine | CHEMBL456583) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama Curated by ChEMBL | Assay Description Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry | Bioorg Med Chem 19: 3558-68 (2011) Article DOI: 10.1016/j.bmc.2011.04.011 BindingDB Entry DOI: 10.7270/Q2BC3ZWW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ceramide glucosyltransferase (Mus musculus) | BDBM50292389 (3-epi-fagomine | 3-epifagomine | CHEMBL456583) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of glucosylceramide synthase in mouse RAW cells preincubated for 15 mins followed by substrate addition and measured after 1 hr by fluores... | ACS Med Chem Lett 2: 519-522 (2011) Article DOI: 10.1021/ml200050s BindingDB Entry DOI: 10.7270/Q28916V8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acidic alpha-glucosidase (Rattus norvegicus) | BDBM50292389 (3-epi-fagomine | 3-epifagomine | CHEMBL456583) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Concentration that causes 50% inhibition of mammalian alpha-glucosidase (maltase) was determined in rat intestine | J Med Chem 37: 3701-6 (1994) BindingDB Entry DOI: 10.7270/Q2ZC83H3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutral alpha-glucosidase C (Mus musculus) | BDBM50292389 (3-epi-fagomine | 3-epifagomine | CHEMBL456583) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Concentration that causes 50% inhibition of mammalian alpha-glucosidase (isomaltase) was determined in rat intestine | J Med Chem 37: 3701-6 (1994) BindingDB Entry DOI: 10.7270/Q2ZC83H3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-glucosidase A (Caldocellum saccharolyticum) | BDBM50292389 (3-epi-fagomine | 3-epifagomine | CHEMBL456583) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Concentration that causes 50% inhibition of mammalian cellobiase beta-glucosidase was determined in rat intestine | J Med Chem 37: 3701-6 (1994) BindingDB Entry DOI: 10.7270/Q2ZC83H3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-L-fucosidase I (Homo sapiens (Human)) | BDBM50292389 (3-epi-fagomine | 3-epifagomine | CHEMBL456583) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Concentration that causes 50% inhibition of mammalian alpha-L-fucosidase was determined in bovine epididymis | J Med Chem 37: 3701-6 (1994) BindingDB Entry DOI: 10.7270/Q2ZC83H3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-galactosidase (Rattus norvegicus) | BDBM50292389 (3-epi-fagomine | 3-epifagomine | CHEMBL456583) | PDB Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Concentration that causes 50% inhibition of mammalian lactase beta-galactosidase was determined in rat intestine | J Med Chem 37: 3701-6 (1994) BindingDB Entry DOI: 10.7270/Q2ZC83H3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-glucosidase (Homo sapiens (Human)) | BDBM50292389 (3-epi-fagomine | 3-epifagomine | CHEMBL456583) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of glucosylceramidase 2 from spleen of patient with gaucher's disease by fluorimetric analysis | ACS Med Chem Lett 2: 519-522 (2011) Article DOI: 10.1021/ml200050s BindingDB Entry DOI: 10.7270/Q28916V8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactase-glycosylceramidase (Rattus norvegicus) | BDBM50292389 (3-epi-fagomine | 3-epifagomine | CHEMBL456583) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Tested for competitive inhibition of rat intestinal lactase | J Med Chem 37: 3701-6 (1994) BindingDB Entry DOI: 10.7270/Q2ZC83H3 | |||||||||||
More data for this Ligand-Target Pair |