null
SMILES: OC[C@@H](O)[C@@H](CO)NCc1c[nH]c2c1nc[nH]c2=O
InChI Key: InChIKey=CGYSFECPLYEOMH-HTQZYQBOSA-N
PDB links: 1 PDB ID matches this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50293091 (7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Industrial Research Limited Curated by ChEMBL | Assay Description Inhibition of human PNP by xanthine-oxidase coupled assay | J Med Chem 52: 1126-43 (2009) Article DOI: 10.1021/jm801421q BindingDB Entry DOI: 10.7270/Q2QR4Z18 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Purine nucleoside phosphorylase (Plasmodium falciparum) | BDBM50293091 (7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a |
Universit£ Montpellier Curated by ChEMBL | Assay Description Binding affinity to Plasmodium falciparum His6-tagged PNP assessed as reduction in uric acid formation using inosine as substrate | J Med Chem 62: 8365-8391 (2019) Article DOI: 10.1021/acs.jmedchem.9b00182 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50293091 (7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB US Patent | n/a | n/a | n/a | 0.00860 | n/a | n/a | n/a | n/a | 25 |
Industrial Research Limited; Albert Einstein College of Medicine of Yeshiva University US Patent | Assay Description The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements... | US Patent US8853224 (2014) BindingDB Entry DOI: 10.7270/Q27H1H84 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Purine nucleoside phosphorylase (Plasmodium falciparum) | BDBM50293091 (7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | 25 |
Industrial Research Limited; Albert Einstein College of Medicine of Yeshiva University US Patent | Assay Description The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements... | US Patent US8853224 (2014) BindingDB Entry DOI: 10.7270/Q27H1H84 | |||||||||||
More data for this Ligand-Target Pair |