BDBM50293242 CHEMBL497198::N4-(5-chlorobenzo[d][1,3]dioxol-4-yl)-N2-(3-(methylsulfonyl)-5-morpholinophenyl)pyrimidine-2,4-diamine
SMILES: CS(=O)(=O)c1cc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)cc(c1)N1CCOCC1
InChI Key: InChIKey=PGOJQQUKXOHEMO-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ephrin type-B receptor 4 (Homo sapiens (Human)) | BDBM50293242 (CHEMBL497198 | N4-(5-chlorobenzo[d][1,3]dioxol-4-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of Myc-His-tagged EphB4 expressed in CHOK1 cells assessed as phosphorylation by ELISA | Bioorg Med Chem Lett 18: 5717-21 (2009) Article DOI: 10.1016/j.bmcl.2008.09.087 BindingDB Entry DOI: 10.7270/Q2N016JJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-B receptor 4 (Homo sapiens (Human)) | BDBM50293242 (CHEMBL497198 | N4-(5-chlorobenzo[d][1,3]dioxol-4-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of EphB4 | Bioorg Med Chem Lett 18: 5717-21 (2009) Article DOI: 10.1016/j.bmcl.2008.09.087 BindingDB Entry DOI: 10.7270/Q2N016JJ | |||||||||||
More data for this Ligand-Target Pair |