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Enter Data

null

SMILES: Clc1ccc2OCOc2c1Nc1ccnc(Nc2cc(cc(c2)N2CCOCC2)N2CCOCC2)n1

InChI Key: InChIKey=IVXGFXACZQBKSB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50293247
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50293247 (CHEMBL468970 \| N4-(5-chlorobenzo[d][1,3]dioxol-4-y...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of EphB4				Bioorg Med Chem Lett 18: 5717-21 (2009) Article DOI: 10.1016/j.bmcl.2008.09.087 BindingDB Entry DOI: 10.7270/Q2N016JJ
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50293247 (CHEMBL468970 \| N4-(5-chlorobenzo[d][1,3]dioxol-4-y...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of Myc-His-tagged EphB4 expressed in CHOK1 cells assessed as phosphorylation by ELISA				Bioorg Med Chem Lett 18: 5717-21 (2009) Article DOI: 10.1016/j.bmcl.2008.09.087 BindingDB Entry DOI: 10.7270/Q2N016JJ
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50293247 (CHEMBL468970 \| N4-(5-chlorobenzo[d][1,3]dioxol-4-y...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of CYP3A4 in human liver microsomes by fluorometric assay				Bioorg Med Chem Lett 20: 6242-5 (2010) Article DOI: 10.1016/j.bmcl.2010.08.100 BindingDB Entry DOI: 10.7270/Q2QR4XCB
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50293247 (CHEMBL468970 \| N4-(5-chlorobenzo[d][1,3]dioxol-4-y...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of EphB4 autophosphorylation expressed in CHOK1 cells				Bioorg Med Chem Lett 20: 6242-5 (2010) Article DOI: 10.1016/j.bmcl.2010.08.100 BindingDB Entry DOI: 10.7270/Q2QR4XCB
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50293247 (CHEMBL468970 \| N4-(5-chlorobenzo[d][1,3]dioxol-4-y...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of EphB4 by acoustic dispensing assay				Bioorg Med Chem Lett 20: 6242-5 (2010) Article DOI: 10.1016/j.bmcl.2010.08.100 BindingDB Entry DOI: 10.7270/Q2QR4XCB
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair