BDBM50293519 2-(6-methylpyridin-2-yl)-N-(pyrimidin-4-yl)quinazolin-4-amine::CHEMBL571452

SMILES: Cc1cccc(n1)-c1nc(Nc2ccncn2)c2ccccc2n1

InChI Key: InChIKey=NTFZYTHOGNVBQR-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50293519   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50293519 (2-(6-methylpyridin-2-yl)-N-(pyrimidin-4-yl)quinazo...) Show SMILES Cc1cccc(n1)-c1nc(Nc2ccncn2)c2ccccc2n1 Show InChI InChI=1S/C18H14N6/c1-12-5-4-8-15(21-12)18-22-14-7-3-2-6-13(14)17(24-18)23-16-9-10-19-11-20-16/h2-11H,1H3,(H,19,20,22,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human ALK5 kinase expressed in Sf9 cells				Bioorg Med Chem Lett 19: 2277-81 (2009) Article DOI: 10.1016/j.bmcl.2009.02.087 BindingDB Entry DOI: 10.7270/Q2K07497
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50293519 (2-(6-methylpyridin-2-yl)-N-(pyrimidin-4-yl)quinazo...) Show SMILES Cc1cccc(n1)-c1nc(Nc2ccncn2)c2ccccc2n1 Show InChI InChI=1S/C18H14N6/c1-12-5-4-8-15(21-12)18-22-14-7-3-2-6-13(14)17(24-18)23-16-9-10-19-11-20-16/h2-11H,1H3,(H,19,20,22,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of GST-fused p38alpha				Bioorg Med Chem Lett 19: 2277-81 (2009) Article DOI: 10.1016/j.bmcl.2009.02.087 BindingDB Entry DOI: 10.7270/Q2K07497
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50293519 (2-(6-methylpyridin-2-yl)-N-(pyrimidin-4-yl)quinazo...) Show SMILES Cc1cccc(n1)-c1nc(Nc2ccncn2)c2ccccc2n1 Show InChI InChI=1S/C18H14N6/c1-12-5-4-8-15(21-12)18-22-14-7-3-2-6-13(14)17(24-18)23-16-9-10-19-11-20-16/h2-11H,1H3,(H,19,20,22,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay				Bioorg Med Chem Lett 19: 2277-81 (2009) Article DOI: 10.1016/j.bmcl.2009.02.087 BindingDB Entry DOI: 10.7270/Q2K07497
					More data for this Ligand-Target Pair