BDBM50293526 2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)thieno[3,2-d]pyrimidin-4-amine::CHEMBL556871
SMILES: Cc1cccc(n1)-c1nc(Nc2ccncc2)c2sccc2n1
InChI Key: InChIKey=WNARUZYWHVAKOP-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50293526 (2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)thieno[3,...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay | Bioorg Med Chem Lett 19: 2277-81 (2009) Article DOI: 10.1016/j.bmcl.2009.02.087 BindingDB Entry DOI: 10.7270/Q2K07497 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50293526 (2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)thieno[3,...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human ALK5 kinase expressed in Sf9 cells | Bioorg Med Chem Lett 19: 2277-81 (2009) Article DOI: 10.1016/j.bmcl.2009.02.087 BindingDB Entry DOI: 10.7270/Q2K07497 | |||||||||||
More data for this Ligand-Target Pair |