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SMILES: Cc1cccc(n1)-c1cc(Nc2ccncc2)c2ccccc2n1

InChI Key: InChIKey=OUYYGKQETOODJA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50293527   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50293527 (2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinolin-...) Show SMILES Cc1cccc(n1)-c1cc(Nc2ccncc2)c2ccccc2n1 Show InChI InChI=1S/C20H16N4/c1-14-5-4-8-18(22-14)20-13-19(23-15-9-11-21-12-10-15)16-6-2-3-7-17(16)24-20/h2-13H,1H3,(H,21,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay				Bioorg Med Chem Lett 19: 2277-81 (2009) Article DOI: 10.1016/j.bmcl.2009.02.087 BindingDB Entry DOI: 10.7270/Q2K07497
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50293527 (2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinolin-...) Show SMILES Cc1cccc(n1)-c1cc(Nc2ccncc2)c2ccccc2n1 Show InChI InChI=1S/C20H16N4/c1-14-5-4-8-18(22-14)20-13-19(23-15-9-11-21-12-10-15)16-6-2-3-7-17(16)24-20/h2-13H,1H3,(H,21,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human ALK5 kinase expressed in Sf9 cells				Bioorg Med Chem Lett 19: 2277-81 (2009) Article DOI: 10.1016/j.bmcl.2009.02.087 BindingDB Entry DOI: 10.7270/Q2K07497
					More data for this Ligand-Target Pair