BDBM50293560 1-Methyl-1H-imidazole-4-carboxylic acid(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide::CHEMBL556247
SMILES: CN1C[C@H]2[C@H](CN(Cc3cccc(OC(F)(F)F)c3)C(=O)c3cn(C)cn3)[C@H]2C1
InChI Key: InChIKey=AZPNIOXCMXPLKP-FVQHAEBGSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glycine transporter 1 (Homo sapiens (Human)) | BDBM50293560 (1-Methyl-1H-imidazole-4-carboxylic acid(3-methyl-3...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Binding affinity to GlyT1 | Bioorg Med Chem Lett 19: 2974-6 (2009) Article DOI: 10.1016/j.bmcl.2009.04.035 BindingDB Entry DOI: 10.7270/Q2F76CKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50293560 (1-Methyl-1H-imidazole-4-carboxylic acid(3-methyl-3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp method | Bioorg Med Chem Lett 19: 2974-6 (2009) Article DOI: 10.1016/j.bmcl.2009.04.035 BindingDB Entry DOI: 10.7270/Q2F76CKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycine transporter 2 (Homo sapiens (Human)) | BDBM50293560 (1-Methyl-1H-imidazole-4-carboxylic acid(3-methyl-3...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]glycine from GlyT2 | Bioorg Med Chem Lett 19: 2974-6 (2009) Article DOI: 10.1016/j.bmcl.2009.04.035 BindingDB Entry DOI: 10.7270/Q2F76CKH | |||||||||||
More data for this Ligand-Target Pair |