BDBM50293743 CHEMBL556667::N-(3-chlorophenyl)picolinamide::cid_836002

SMILES: Clc1cccc(NC(=O)c2ccccn2)c1

InChI Key: InChIKey=SUYUTNCKIOLMAJ-UHFFFAOYSA-N

Data: 13 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50293743   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human))	BDBM50293743 (CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2VT1QHF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50293743 (CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	377	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2R20ZS1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8) (Rattus norvegicus (Rat))	BDBM50293743 (CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	1.35E+4	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2T1523G
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7) (Rattus norvegicus (Rat))	BDBM50293743 (CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	2.35E+5	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2P849B9
					More data for this Ligand-Target Pair
glutamate receptor, metabotropic 4 precursor (Rattus norvegicus)	BDBM50293743 (CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)	PDB KEGG GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	9.84E+3	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptom...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2JH3JMK
					More data for this Ligand-Target Pair
glutamate receptor, metabotropic 4 precursor (Rattus norvegicus)	BDBM50293743 (CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)	PDB KEGG GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	295	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2DR2SWV
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50293743 (CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...				Bioorg Med Chem Lett 28: 2641-2646 (2018) Article DOI: 10.1016/j.bmcl.2018.06.034 BindingDB Entry DOI: 10.7270/Q2DR2Z5H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50293743 (CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	5.36E+3	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2WS8RPQ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human))	BDBM50293743 (CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor				Bioorg Med Chem Lett 25: 3956-60 (2015) BindingDB Entry DOI: 10.7270/Q28C9Z1B
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4) (Rattus norvegicus (Rat))	BDBM50293743 (CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	330	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Positive allosteric modulator activity at rat mGlu4 receptor				Bioorg Med Chem Lett 25: 3956-60 (2015) BindingDB Entry DOI: 10.7270/Q28C9Z1B
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4) (Rattus norvegicus (Rat))	BDBM50293743 (CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Activity at rat mGluR4 receptor expressed in HEK293 cells assessed as effect on thallium flux				J Med Chem 52: 4115-8 (2009) Article DOI: 10.1021/jm9005065 BindingDB Entry DOI: 10.7270/Q2RJ4JHT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human))	BDBM50293743 (CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Activity at human mGluR4 receptor expressed in CHO cells assessed as effect on calcium mobilization				J Med Chem 52: 4115-8 (2009) Article DOI: 10.1021/jm9005065 BindingDB Entry DOI: 10.7270/Q2RJ4JHT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50293743 (CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	728	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptom...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q21J985D
					More data for this Ligand-Target Pair