BDBM50293986 (R)-5-Bromo-1-(1-cyclopropylethyl)-3-[6-methoxy-2-(trifluoromethyl)pyridin-3-ylamino]pyrazin-2(1H)-one::CHEMBL556462

SMILES: COc1ccc(Nc2nc(Br)cn([C@H](C)C3CC3)c2=O)c(n1)C(F)(F)F

InChI Key: InChIKey=WKFBQUBJJKWBIJ-MRVPVSSYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50293986   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor (Rattus norvegicus (rat))	BDBM50293986 ((R)-5-Bromo-1-(1-cyclopropylethyl)-3-[6-methoxy-2-...) Show SMILES COc1ccc(Nc2nc(Br)cn([C@H](C)C3CC3)c2=O)c(n1)C(F)(F)F |r| Show InChI InChI=1S/C16H16BrF3N4O2/c1-8(9-3-4-9)24-7-11(17)22-14(15(24)25)21-10-5-6-12(26-2)23-13(10)16(18,19)20/h5-9H,3-4H2,1-2H3,(H,21,22)/t8-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Displacement of [125I]Tyr-ovine-CRF from CRF1 receptor in rat frontal cortex homogenate by gamma counting				J Med Chem 52: 4173-91 (2009) Article DOI: 10.1021/jm900301y BindingDB Entry DOI: 10.7270/Q2G44Q9K
					More data for this Ligand-Target Pair