BDBM50294198 2-(6-(4-chlorophenyl)-2,2-diethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-N-(methylsulfonyl)acetamide::CHEMBL560898

SMILES: CCC1(CC)Cc2c(c(c(CC(=O)NS(C)(=O)=O)n2C1)-c1ccc(Cl)cc1)-c1ccccc1

InChI Key: InChIKey=CVXUNMJWDZEXJI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50294198   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E synthase (Homo sapiens (Human))	BDBM50294198 (2-(6-(4-chlorophenyl)-2,2-diethyl-7-phenyl-2,3-dih...) Show SMILES CCC1(CC)Cc2c(c(c(CC(=O)NS(C)(=O)=O)n2C1)-c1ccc(Cl)cc1)-c1ccccc1 Show InChI InChI=1S/C26H29ClN2O3S/c1-4-26(5-2)16-22-25(18-9-7-6-8-10-18)24(19-11-13-20(27)14-12-19)21(29(22)17-26)15-23(30)28-33(3,31)32/h6-14H,4-5,15-17H2,1-3H3,(H,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard Karls University Tuebingen Curated by ChEMBL					Assay Description Inhibition of mPGES1 in IL-1beta treated human A549 cell microsomal membrane assessed as residual enzyme activity after 1 min by measuring PGE2 level...				J Med Chem 52: 4968-72 (2009) Article DOI: 10.1021/jm900481c BindingDB Entry DOI: 10.7270/Q29C6XGX
					More data for this Ligand-Target Pair