BDBM50294765 CHEMBL551306::N-Adamantan-2-yl-2-{1-[(4-fluoro-phenylcarbamoyl)-methyl]-cyclopentyl}-acetamide

SMILES: Fc1ccc(NC(=O)CC2(CC(=O)NC3C4CC5CC(C4)CC3C5)CCCC2)cc1

InChI Key: InChIKey=CQACWQWCNUVOLT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50294765   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50294765 (CHEMBL551306 | N-Adamantan-2-yl-2-{1-[(4-fluoro-ph...) Show SMILES Fc1ccc(NC(=O)CC2(CC(=O)NC3C4CC5CC(C4)CC3C5)CCCC2)cc1 |TLB:20:19:23:16.15.14,20:15:18.19.21:23,THB:14:15:18:21.22.23,14:22:18:16.20.15,13:14:18.19.21:23,(8.39,2.65,;7.05,3.42,;5.72,2.65,;4.39,3.41,;4.39,4.96,;3.05,5.73,;1.72,4.96,;1.72,3.42,;.38,5.72,;-.95,4.95,;-2.28,5.72,;-3.61,4.94,;-3.61,3.4,;-4.95,5.71,;-6.23,4.85,;-6.24,3.33,;-7.64,2.98,;-8.97,3.46,;-10.16,2.19,;-8.66,2.61,;-7.26,2.05,;-8.67,4.2,;-7.63,5.43,;-8.98,4.95,;-2.19,4.03,;-1.7,2.57,;-.16,2.59,;.31,4.06,;5.71,5.73,;7.04,4.97,)| Show InChI InChI=1S/C25H33FN2O2/c26-20-3-5-21(6-4-20)27-22(29)14-25(7-1-2-8-25)15-23(30)28-24-18-10-16-9-17(12-18)13-19(24)11-16/h3-6,16-19,24H,1-2,7-15H2,(H,27,29)(H,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Merck-Serono Curated by ChEMBL					Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as cortisol level after 150 mins by HTRF assay				Bioorg Med Chem Lett 19: 2674-8 (2009) Article DOI: 10.1016/j.bmcl.2009.03.140 BindingDB Entry DOI: 10.7270/Q2JQ112H
					More data for this Ligand-Target Pair