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BDBM50295239 11-(2-chloro-6-fluorophenyl)-3,3-dimethyl-8-(trifluoromethoxy)-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one::CHEMBL552191

SMILES: CC1(C)CC(=O)C2C(Nc3cc(OC(F)(F)F)ccc3N=C2C1)c1c(F)cccc1Cl

InChI Key: InChIKey=AMQJZZHOCHGQCX-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50295239   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
NMBR


(Homo sapiens (Human))		BDBM50295239
PNG
(11-(2-chloro-6-fluorophenyl)-3,3-dimethyl-8-(trifl...)
Show SMILES CC1(C)CC(=O)C2C(Nc3cc(OC(F)(F)F)ccc3N=C2C1)c1c(F)cccc1Cl |c:21|
Show InChI InChI=1S/C22H19ClF4N2O2/c1-21(2)9-16-19(17(30)10-21)20(18-12(23)4-3-5-13(18)24)29-15-8-11(31-22(25,26)27)6-7-14(15)28-16/h3-8,19-20,29H,9-10H2,1-2H3
KEGG

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PC sid
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Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells

Bioorg Med Chem Lett 19: 4264-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.124
BindingDB Entry DOI: 10.7270/Q2C24WG8
More data for this
Ligand-Target Pair