BDBM50295518 2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin-1-yl]-N-(4-methoxyphenyl)-acetamide::CHEMBL562910

SMILES: COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1

InChI Key: InChIKey=HERIZPADSDINJL-UHFFFAOYSA-N

Data: 6 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50295518   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
fMet-Leu-Phe receptor (Homo sapiens (Human))	BDBM50295518 (2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...) Show SMILES COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 Show InChI InChI=1S/C22H23N3O4/c1-15-11-17(12-16-5-4-6-20(13-16)29-3)22(27)25(24-15)14-21(26)23-18-7-9-19(28-2)10-8-18/h4-11,13H,12,14H2,1-3H3,(H,23,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze Curated by ChEMBL					Assay Description Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay				J Med Chem 52: 5044-57 (2010) Article DOI: 10.1021/jm900592h BindingDB Entry DOI: 10.7270/Q2WS8T85
					More data for this Ligand-Target Pair
fMet-Leu-Phe receptor (Homo sapiens (Human))	BDBM50295518 (2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...) Show SMILES COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 Show InChI InChI=1S/C22H23N3O4/c1-15-11-17(12-16-5-4-6-20(13-16)29-3)22(27)25(24-15)14-21(26)23-18-7-9-19(28-2)10-8-18/h4-11,13H,12,14H2,1-3H3,(H,23,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	77	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze Curated by ChEMBL					Assay Description Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay				J Med Chem 52: 5044-57 (2010) Article DOI: 10.1021/jm900592h BindingDB Entry DOI: 10.7270/Q2WS8T85
					More data for this Ligand-Target Pair
N-formyl peptide receptor 2 (Homo sapiens (Human))	BDBM50295518 (2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...) Show SMILES COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 Show InChI InChI=1S/C22H23N3O4/c1-15-11-17(12-16-5-4-6-20(13-16)29-3)22(27)25(24-15)14-21(26)23-18-7-9-19(28-2)10-8-18/h4-11,13H,12,14H2,1-3H3,(H,23,26)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.44E+4	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze Curated by ChEMBL					Assay Description Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay				J Med Chem 52: 5044-57 (2010) Article DOI: 10.1021/jm900592h BindingDB Entry DOI: 10.7270/Q2WS8T85
					More data for this Ligand-Target Pair
N-formyl peptide receptor 2 (Homo sapiens (Human))	BDBM50295518 (2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...) Show SMILES COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 Show InChI InChI=1S/C22H23N3O4/c1-15-11-17(12-16-5-4-6-20(13-16)29-3)22(27)25(24-15)14-21(26)23-18-7-9-19(28-2)10-8-18/h4-11,13H,12,14H2,1-3H3,(H,23,26)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze Curated by ChEMBL					Assay Description Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay				J Med Chem 52: 5044-57 (2010) Article DOI: 10.1021/jm900592h BindingDB Entry DOI: 10.7270/Q2WS8T85
					More data for this Ligand-Target Pair
N-formyl peptide receptor 2 (Homo sapiens (Human))	BDBM50295518 (2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...) Show SMILES COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 Show InChI InChI=1S/C22H23N3O4/c1-15-11-17(12-16-5-4-6-20(13-16)29-3)22(27)25(24-15)14-21(26)23-18-7-9-19(28-2)10-8-18/h4-11,13H,12,14H2,1-3H3,(H,23,26)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze Curated by ChEMBL					Assay Description Agonist activity at FPRL1 in human neutrophiles by chemotaxis assay				J Med Chem 52: 5044-57 (2010) Article DOI: 10.1021/jm900592h BindingDB Entry DOI: 10.7270/Q2WS8T85
					More data for this Ligand-Target Pair
fMet-Leu-Phe receptor (Homo sapiens (Human))	BDBM50295518 (2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...) Show SMILES COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 Show InChI InChI=1S/C22H23N3O4/c1-15-11-17(12-16-5-4-6-20(13-16)29-3)22(27)25(24-15)14-21(26)23-18-7-9-19(28-2)10-8-18/h4-11,13H,12,14H2,1-3H3,(H,23,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze Curated by ChEMBL					Assay Description Agonist activity at FPR1 in human neutrophiles by chemotaxis assay				J Med Chem 52: 5044-57 (2010) Article DOI: 10.1021/jm900592h BindingDB Entry DOI: 10.7270/Q2WS8T85
					More data for this Ligand-Target Pair