BDBM50295527 2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin-1-yl]-Nphenyl-acetamide::CHEMBL561375

SMILES: COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1

InChI Key: InChIKey=QHCUAHHQVNFYCR-UHFFFAOYSA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50295527   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
N-formyl peptide receptor 2 (Homo sapiens (Human))	BDBM50295527 (2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...) Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1 Show InChI InChI=1S/C21H21N3O3/c1-15-11-17(12-16-7-6-10-19(13-16)27-2)21(26)24(23-15)14-20(25)22-18-8-4-3-5-9-18/h3-11,13H,12,14H2,1-2H3,(H,22,25)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze Curated by ChEMBL					Assay Description Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay				J Med Chem 52: 5044-57 (2010) Article DOI: 10.1021/jm900592h BindingDB Entry DOI: 10.7270/Q2WS8T85
					More data for this Ligand-Target Pair
N-formyl peptide receptor 2 (Homo sapiens (Human))	BDBM50295527 (2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...) Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1 Show InChI InChI=1S/C21H21N3O3/c1-15-11-17(12-16-7-6-10-19(13-16)27-2)21(26)24(23-15)14-20(25)22-18-8-4-3-5-9-18/h3-11,13H,12,14H2,1-2H3,(H,22,25)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	600	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze Curated by ChEMBL					Assay Description Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay				J Med Chem 52: 5044-57 (2010) Article DOI: 10.1021/jm900592h BindingDB Entry DOI: 10.7270/Q2WS8T85
					More data for this Ligand-Target Pair
fMet-Leu-Phe receptor (Homo sapiens (Human))	BDBM50295527 (2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...) Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1 Show InChI InChI=1S/C21H21N3O3/c1-15-11-17(12-16-7-6-10-19(13-16)27-2)21(26)24(23-15)14-20(25)22-18-8-4-3-5-9-18/h3-11,13H,12,14H2,1-2H3,(H,22,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	32	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze Curated by ChEMBL					Assay Description Agonist activity at FPR1 in human neutrophiles by chemotaxis assay				J Med Chem 52: 5044-57 (2010) Article DOI: 10.1021/jm900592h BindingDB Entry DOI: 10.7270/Q2WS8T85
					More data for this Ligand-Target Pair
fMet-Leu-Phe receptor (Homo sapiens (Human))	BDBM50295527 (2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...) Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1 Show InChI InChI=1S/C21H21N3O3/c1-15-11-17(12-16-7-6-10-19(13-16)27-2)21(26)24(23-15)14-20(25)22-18-8-4-3-5-9-18/h3-11,13H,12,14H2,1-2H3,(H,22,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	32	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze Curated by ChEMBL					Assay Description Agonist activity at FPR1 in human neutrophiles by chemotaxis assay				J Med Chem 52: 5044-57 (2010) Article DOI: 10.1021/jm900592h BindingDB Entry DOI: 10.7270/Q2WS8T85
					More data for this Ligand-Target Pair