BDBM50295881 4-(1H-indol-3-yl)-5-(4-(trifluoromethoxy)phenyl)pyrimidin-2-amine::CHEMBL562648

SMILES: Nc1ncc(-c2ccc(OC(F)(F)F)cc2)c(n1)-c1c[nH]c2ccccc12

InChI Key: InChIKey=CPJHSQQFFZFVLU-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50295881   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (RAT)	BDBM50295881 (4-(1H-indol-3-yl)-5-(4-(trifluoromethoxy)phenyl)py...) Show SMILES Nc1ncc(-c2ccc(OC(F)(F)F)cc2)c(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C19H13F3N4O/c20-19(21,22)27-12-7-5-11(6-8-12)14-9-25-18(23)26-17(14)15-10-24-16-4-2-1-3-13(15)16/h1-10,24H,(H2,23,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Clermont Universit£ Curated by ChEMBL					Assay Description Inhibition of rat recombinant DYRK1A expressed in Escherichia coli				Bioorg Med Chem 17: 4420-4 (2009) Article DOI: 10.1016/j.bmc.2009.05.017 BindingDB Entry DOI: 10.7270/Q2639PSH
					More data for this Ligand-Target Pair
Cyclin-dependent-like kinase 5 (Homo sapiens (Human))	BDBM50295881 (4-(1H-indol-3-yl)-5-(4-(trifluoromethoxy)phenyl)py...) Show SMILES Nc1ncc(-c2ccc(OC(F)(F)F)cc2)c(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C19H13F3N4O/c20-19(21,22)27-12-7-5-11(6-8-12)14-9-25-18(23)26-17(14)15-10-24-16-4-2-1-3-13(15)16/h1-10,24H,(H2,23,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Clermont Universit£ Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK5/p25				Bioorg Med Chem 17: 4420-4 (2009) Article DOI: 10.1016/j.bmc.2009.05.017 BindingDB Entry DOI: 10.7270/Q2639PSH
					More data for this Ligand-Target Pair
ERK-2 (Rattus norvegicus (rat))	BDBM50295881 (4-(1H-indol-3-yl)-5-(4-(trifluoromethoxy)phenyl)py...) Show SMILES Nc1ncc(-c2ccc(OC(F)(F)F)cc2)c(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C19H13F3N4O/c20-19(21,22)27-12-7-5-11(6-8-12)14-9-25-18(23)26-17(14)15-10-24-16-4-2-1-3-13(15)16/h1-10,24H,(H2,23,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Clermont Universit£ Curated by ChEMBL					Assay Description Inhibition of rat recombinant Erk2				Bioorg Med Chem 17: 4420-4 (2009) Article DOI: 10.1016/j.bmc.2009.05.017 BindingDB Entry DOI: 10.7270/Q2639PSH
					More data for this Ligand-Target Pair