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BDBM50295926 4'-O-methylhonokiol, MH::4-methoxyhonokiol::5,3'-Diallyl-4'-methoxy-biphenyl-2-ol::CHEMBL89700::Magreth-14a::Methylhonokiol

SMILES: COc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O

InChI Key: InChIKey=OQFHJKZVOALSPV-UHFFFAOYSA-N

Data: 5 KI  3 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50295926   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50295926
PNG
(4'-O-methylhonokiol, MH | 4-methoxyhonokiol | ...)
Show SMILES COc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O
Show InChI InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3
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43.9n/an/an/an/an/an/an/an/a



University of Bern



Assay Description
Binding assay with hCB1 and hCB2 receptors.


Chem Biol 18: 1053-64 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.012
BindingDB Entry DOI: 10.7270/Q27W69PQ
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50295926
PNG
(4'-O-methylhonokiol, MH | 4-methoxyhonokiol | ...)
Show SMILES COc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O
Show InChI InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3
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44n/an/an/an/an/an/an/an/a



PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn , An der Immenburg 4, D-53121 Bonn, Germany.

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55,940 from recombinant human CB2 receptor expressed in CHO cells after 2 hrs by liquid scintillation counting


ACS Med Chem Lett 4: 41-5 (2013)


Article DOI: 10.1021/ml300235q
BindingDB Entry DOI: 10.7270/Q2SF2XHW
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50295926
PNG
(4'-O-methylhonokiol, MH | 4-methoxyhonokiol | ...)
Show SMILES COc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O
Show InChI InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3
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138n/an/an/an/an/an/an/an/a



University of Bern



Assay Description
Binding assay with hCB1 and hCB2 receptors.


Chem Biol 18: 1053-64 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.012
BindingDB Entry DOI: 10.7270/Q27W69PQ
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50295926
PNG
(4'-O-methylhonokiol, MH | 4-methoxyhonokiol | ...)
Show SMILES COc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O
Show InChI InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3
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790n/an/an/an/an/an/an/an/a



University of Bern



Assay Description
Binding assay with hCB1 and hCB2 receptors.


Chem Biol 18: 1053-64 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.012
BindingDB Entry DOI: 10.7270/Q27W69PQ
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50295926
PNG
(4'-O-methylhonokiol, MH | 4-methoxyhonokiol | ...)
Show SMILES COc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O
Show InChI InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3
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2.40E+3n/an/an/an/an/an/an/an/a



University of Bern



Assay Description
Binding assay with hCB1 and hCB2 receptors.


Chem Biol 18: 1053-64 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.012
BindingDB Entry DOI: 10.7270/Q27W69PQ
More data for this
Ligand-Target Pair
GABA-A receptor; GABA-A site (alpha1/beta2 interface)


(Homo sapiens (Human))
BDBM50295926
PNG
(4'-O-methylhonokiol, MH | 4-methoxyhonokiol | ...)
Show SMILES COc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O
Show InChI InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3
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n/an/an/an/a 2.72E+4n/an/an/an/a



University of Vienna

Curated by ChEMBL


Assay Description
Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding pot...


J Med Chem 54: 5349-61 (2011)


Article DOI: 10.1021/jm200186n
BindingDB Entry DOI: 10.7270/Q2QR4XGP
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50295926
PNG
(4'-O-methylhonokiol, MH | 4-methoxyhonokiol | ...)
Show SMILES COc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O
Show InChI InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Karl-Franzens-Universit£t Graz

Curated by ChEMBL


Assay Description
Inhibition of 5LOX-mediated LTB4 formation in stimulated human polymorphonuclear leukocytes


Bioorg Med Chem 17: 4459-65 (2009)


Article DOI: 10.1016/j.bmc.2009.05.018
BindingDB Entry DOI: 10.7270/Q2SX6D9B
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (Cyclooxygenase-2)


(Ovis aries (Sheep))
BDBM50295926
PNG
(4'-O-methylhonokiol, MH | 4-methoxyhonokiol | ...)
Show SMILES COc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O
Show InChI InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3
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n/an/a 60n/an/an/an/an/an/a



Karl-Franzens-Universit£t Graz

Curated by ChEMBL


Assay Description
Inhibition of COX2 in sheep placental vesicle by enzyme immunoassay


Bioorg Med Chem 17: 4459-65 (2009)


Article DOI: 10.1016/j.bmc.2009.05.018
BindingDB Entry DOI: 10.7270/Q2SX6D9B
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50295926
PNG
(4'-O-methylhonokiol, MH | 4-methoxyhonokiol | ...)
Show SMILES COc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O
Show InChI InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3
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n/an/a 100n/an/an/an/an/an/a



Karl-Franzens-Universit£t Graz

Curated by ChEMBL


Assay Description
Inhibition of COX1 in ram seminal vesicle by enzyme immunoassay


Bioorg Med Chem 17: 4459-65 (2009)


Article DOI: 10.1016/j.bmc.2009.05.018
BindingDB Entry DOI: 10.7270/Q2SX6D9B
More data for this
Ligand-Target Pair