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SMILES: Nc1nccn2cnc(-c3ccc4ccc(nc4c3C3CC(C3)N3CC3)-c3ccccc3)c12

InChI Key: InChIKey=XZPOMUAGEPUDKY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50296353   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50296353 (1-(8-(3-(aziridin-1-yl)cyclobutyl)-2-phenylquinoli...) Show SMILES Nc1nccn2cnc(-c3ccc4ccc(nc4c3C3CC(C3)N3CC3)-c3ccccc3)c12 |(-8.5,-15.87,;-8.8,-17.38,;-10.25,-17.89,;-10.54,-19.41,;-9.38,-20.41,;-7.93,-19.91,;-6.59,-20.65,;-5.47,-19.61,;-6.12,-18.22,;-5.37,-16.87,;-6.17,-15.56,;-5.43,-14.22,;-3.88,-14.18,;-3.13,-12.84,;-1.59,-12.81,;-.79,-14.14,;-1.55,-15.49,;-3.09,-15.51,;-3.84,-16.85,;-3.05,-18.18,;-3.43,-19.67,;-1.94,-20.05,;-1.56,-18.56,;-1.15,-21.37,;-1.13,-22.9,;.19,-22.11,;.75,-14.12,;1.54,-15.44,;3.07,-15.42,;3.82,-14.07,;3.02,-12.74,;1.49,-12.78,;-7.64,-18.4,)| Show InChI InChI=1S/C27H24N6/c28-27-26-25(30-16-33(26)11-10-29-27)21-8-6-18-7-9-22(17-4-2-1-3-5-17)31-24(18)23(21)19-14-20(15-19)32-12-13-32/h1-11,16,19-20H,12-15H2,(H2,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Inhibition of IGF1R				J Med Chem 52: 4981-5004 (2010) Article DOI: 10.1021/jm9002395 BindingDB Entry DOI: 10.7270/Q2P84CTD
					More data for this Ligand-Target Pair