null

SMILES: CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1[nH]nc2CCN(Cc12)S(=O)(=O)c1cc(F)cc(F)c1

InChI Key: InChIKey=FYWUYAPXFLZJIW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50296354   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50296354 (CHEMBL549369 | N-(5-(3,5-difluorophenylsulfonyl)-4...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1[nH]nc2CCN(Cc12)S(=O)(=O)c1cc(F)cc(F)c1 Show InChI InChI=1S/C24H26F2N6O3S/c1-30-8-10-31(11-9-30)19-4-2-16(3-5-19)24(33)27-23-21-15-32(7-6-22(21)28-29-23)36(34,35)20-13-17(25)12-18(26)14-20/h2-5,12-14H,6-11,15H2,1H3,(H2,27,28,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Inhibition for IGF1R-induced S6 ribosomal protein phosphorylation in growth factor-stimulated NHDF				J Med Chem 52: 4981-5004 (2010) Article DOI: 10.1021/jm9002395 BindingDB Entry DOI: 10.7270/Q2P84CTD
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50296354 (CHEMBL549369 | N-(5-(3,5-difluorophenylsulfonyl)-4...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1[nH]nc2CCN(Cc12)S(=O)(=O)c1cc(F)cc(F)c1 Show InChI InChI=1S/C24H26F2N6O3S/c1-30-8-10-31(11-9-30)19-4-2-16(3-5-19)24(33)27-23-21-15-32(7-6-22(21)28-29-23)36(34,35)20-13-17(25)12-18(26)14-20/h2-5,12-14H,6-11,15H2,1H3,(H2,27,28,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Inhibition of IGF1R in growth factor-stimulated NHDF				J Med Chem 52: 4981-5004 (2010) Article DOI: 10.1021/jm9002395 BindingDB Entry DOI: 10.7270/Q2P84CTD
					More data for this Ligand-Target Pair