BindingDB PrimarySearch

BDBM50296357 4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methylene)dibenzene-1,2-diol::CHEMBL551264

SMILES: Oc1ccc(CN(Cc2ccc(O)c(O)c2)c2ccc3OCOc3c2)cc1O

InChI Key: InChIKey=FQPNWTQWSMOJRB-UHFFFAOYSA-N

Data: 7 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50296357
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Insulin receptor (Homo sapiens (Human))	BDBM50296357 (4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methyl...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human insulin receptor-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50296357 (4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of IGF1R-mediated colony formation in human LNCaP cells after 12 days by MTT assay				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50296357 (4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of IGF1R-mediated colony formation in human MCF7 cells after 12 days by MTT assay				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50296357 (4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
University of South Florida Curated by ChEMBL					Assay Description Inhibition of IGF1R				J Med Chem 52: 4981-5004 (2010) Article DOI: 10.1021/jm9002395 BindingDB Entry DOI: 10.7270/Q2P84CTD
University of South Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50296357 (4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human IGF1R-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50296357 (4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methyl...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human GST-fused Src-mediated Poly Glu4Tyr phosphorylation by ELISA				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50296357 (4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of IGF1R-mediated colony formation in human PC3 cells after 12 days by MTT assay				Eur J Pharmacol 562: 1-11 (2007) Article DOI: 10.1016/j.ejphar.2007.01.052 BindingDB Entry DOI: 10.7270/Q2VD6ZPB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair