BDBM50296589 (1S,3R)-N-((4-chloro-5-(3,5-difluorophenyl)-1-methyl-1H-pyrazol-3-yl)methyl)-3-fluorocyclopentanamine::CHEMBL560468

SMILES: Cn1nc(CN[C@H]2CC[C@@H](F)C2)c(Cl)c1-c1cc(F)cc(F)c1

InChI Key: InChIKey=OFBXDLVRMTULIV-MFKMUULPSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50296589   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM50296589 ((1S,3R)-N-((4-chloro-5-(3,5-difluorophenyl)-1-meth...) Show SMILES Cn1nc(CN[C@H]2CC[C@@H](F)C2)c(Cl)c1-c1cc(F)cc(F)c1 |r| Show InChI InChI=1S/C16H17ClF3N3/c1-23-16(9-4-11(19)6-12(20)5-9)15(17)14(22-23)8-21-13-3-2-10(18)7-13/h4-6,10,13,21H,2-3,7-8H2,1H3/t10-,13+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]Tyr14-NC/OFQ from ORL1 receptor				Bioorg Med Chem Lett 19: 4729-32 (2009) Article DOI: 10.1016/j.bmcl.2009.06.051 BindingDB Entry DOI: 10.7270/Q2H9958F
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50296589 ((1S,3R)-N-((4-chloro-5-(3,5-difluorophenyl)-1-meth...) Show SMILES Cn1nc(CN[C@H]2CC[C@@H](F)C2)c(Cl)c1-c1cc(F)cc(F)c1 |r| Show InChI InChI=1S/C16H17ClF3N3/c1-23-16(9-4-11(19)6-12(20)5-9)15(17)14(22-23)8-21-13-3-2-10(18)7-13/h4-6,10,13,21H,2-3,7-8H2,1H3/t10-,13+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at ORL1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 19: 4729-32 (2009) Article DOI: 10.1016/j.bmcl.2009.06.051 BindingDB Entry DOI: 10.7270/Q2H9958F
					More data for this Ligand-Target Pair