null

SMILES: CC(C)c1c(CNC2CCCC2)nc(-c2ncccc2Cl)n1-c1ccc(C)nc1

InChI Key: InChIKey=BOWSGWFJDZSKQS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50296913   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM50296913 (CHEMBL561396 | N-((2-(3-chloropyridin-2-yl)-5-isop...) Show SMILES CC(C)c1c(CNC2CCCC2)nc(-c2ncccc2Cl)n1-c1ccc(C)nc1 Show InChI InChI=1S/C23H28ClN5/c1-15(2)22-20(14-27-17-7-4-5-8-17)28-23(21-19(24)9-6-12-25-21)29(22)18-11-10-16(3)26-13-18/h6,9-13,15,17,27H,4-5,7-8,14H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50296913 (CHEMBL561396 | N-((2-(3-chloropyridin-2-yl)-5-isop...) Show SMILES CC(C)c1c(CNC2CCCC2)nc(-c2ncccc2Cl)n1-c1ccc(C)nc1 Show InChI InChI=1S/C23H28ClN5/c1-15(2)22-20(14-27-17-7-4-5-8-17)28-23(21-19(24)9-6-12-25-21)29(22)18-11-10-16(3)26-13-18/h6,9-13,15,17,27H,4-5,7-8,14H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [35S]MK499 from human ERG expressed in HEK293 cells overexpressing Ikr channel protein				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50296913 (CHEMBL561396 | N-((2-(3-chloropyridin-2-yl)-5-isop...) Show SMILES CC(C)c1c(CNC2CCCC2)nc(-c2ncccc2Cl)n1-c1ccc(C)nc1 Show InChI InChI=1S/C23H28ClN5/c1-15(2)22-20(14-27-17-7-4-5-8-17)28-23(21-19(24)9-6-12-25-21)29(22)18-11-10-16(3)26-13-18/h6,9-13,15,17,27H,4-5,7-8,14H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned ORL1 receptor expressed in CHO cells assessed as inhibition of nociceptin/orphanin FQ-stimulated [35S]GTPgammaS b...				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair