BDBM50297131 CHEMBL564143::endo-N-(3-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2,2-diphenylpropyl)benzenesulfonamide

SMILES: CN1[C@@H]2CC[C@@H]1CC(CC(CNS(=O)(=O)c1ccccc1)(c1ccccc1)c1ccccc1)C2

InChI Key: InChIKey=LVAXIKIVPNIRLY-KAYWLYCHSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50297131   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50297131 (CHEMBL564143 | endo-N-(3-(8-methyl-8-azabicyclo[3....) Show SMILES CN1[C@@H]2CC[C@@H]1CC(CC(CNS(=O)(=O)c1ccccc1)(c1ccccc1)c1ccccc1)C2 |r,TLB:0:1:7.33.6:3.4,THB:8:7:1:3.4| Show InChI InChI=1S/C29H34N2O2S/c1-31-26-17-18-27(31)20-23(19-26)21-29(24-11-5-2-6-12-24,25-13-7-3-8-14-25)22-30-34(32,33)28-15-9-4-10-16-28/h2-16,23,26-27,30H,17-22H2,1H3/t26-,27-/m1/s1	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity against human cloned muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...				Bioorg Med Chem Lett 19: 4560-2 (2009) Article DOI: 10.1016/j.bmcl.2009.07.006 BindingDB Entry DOI: 10.7270/Q2DB81WW
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50297131 (CHEMBL564143 | endo-N-(3-(8-methyl-8-azabicyclo[3....) Show SMILES CN1[C@@H]2CC[C@@H]1CC(CC(CNS(=O)(=O)c1ccccc1)(c1ccccc1)c1ccccc1)C2 |r,TLB:0:1:7.33.6:3.4,THB:8:7:1:3.4| Show InChI InChI=1S/C29H34N2O2S/c1-31-26-17-18-27(31)20-23(19-26)21-29(24-11-5-2-6-12-24,25-13-7-3-8-14-25)22-30-34(32,33)28-15-9-4-10-16-28/h2-16,23,26-27,30H,17-22H2,1H3/t26-,27-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR				J Med Chem 52: 5241-52 (2010) Article DOI: 10.1021/jm900736e BindingDB Entry DOI: 10.7270/Q2PK0H54
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50297131 (CHEMBL564143 | endo-N-(3-(8-methyl-8-azabicyclo[3....) Show SMILES CN1[C@@H]2CC[C@@H]1CC(CC(CNS(=O)(=O)c1ccccc1)(c1ccccc1)c1ccccc1)C2 |r,TLB:0:1:7.33.6:3.4,THB:8:7:1:3.4| Show InChI InChI=1S/C29H34N2O2S/c1-31-26-17-18-27(31)20-23(19-26)21-29(24-11-5-2-6-12-24,25-13-7-3-8-14-25)22-30-34(32,33)28-15-9-4-10-16-28/h2-16,23,26-27,30H,17-22H2,1H3/t26-,27-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...				Bioorg Med Chem Lett 19: 4560-2 (2009) Article DOI: 10.1016/j.bmcl.2009.07.006 BindingDB Entry DOI: 10.7270/Q2DB81WW
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50297131 (CHEMBL564143 | endo-N-(3-(8-methyl-8-azabicyclo[3....) Show SMILES CN1[C@@H]2CC[C@@H]1CC(CC(CNS(=O)(=O)c1ccccc1)(c1ccccc1)c1ccccc1)C2 |r,TLB:0:1:7.33.6:3.4,THB:8:7:1:3.4| Show InChI InChI=1S/C29H34N2O2S/c1-31-26-17-18-27(31)20-23(19-26)21-29(24-11-5-2-6-12-24,25-13-7-3-8-14-25)22-30-34(32,33)28-15-9-4-10-16-28/h2-16,23,26-27,30H,17-22H2,1H3/t26-,27-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	458	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...				Bioorg Med Chem Lett 19: 4560-2 (2009) Article DOI: 10.1016/j.bmcl.2009.07.006 BindingDB Entry DOI: 10.7270/Q2DB81WW
					More data for this Ligand-Target Pair