BDBM50297170 7-(2'-spiroindanyl)oxymorphone::7-(Spiroindano)Oxymorphone::7-spiroindanyloxymorphone::CHEMBL399708::SIOM::Spiroindanyloxymorphone
SMILES: CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@]3(O)CC1(Cc2ccccc2C1)C4=O)ccc5O
InChI Key: InChIKey=YJWDKWRVFJZBCJ-QVJDATKISA-N
Data: 20 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Antagonism against bradykinin receptor B2 in guinea pig ileal tissue | J Med Chem 36: 2572-4 (1993) BindingDB Entry DOI: 10.7270/Q27H1K62 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description The compound tested for agonistic activity against Opioid receptor delta 1 using [3H]- NT1 as the radioligand. | J Med Chem 40: 1720-5 (1997) Article DOI: 10.1021/jm9700880 BindingDB Entry DOI: 10.7270/Q2FB53M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (MOUSE) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of [3H]-NTI binding to Opioid receptor delta 1 from mouse brain membranes. | J Med Chem 40: 3064-70 (1997) Article DOI: 10.1021/jm970283e BindingDB Entry DOI: 10.7270/Q27D2T7R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Selective binding affinity against Opioid receptor delta 2, using [3H]DSLET as radioligand | J Med Chem 36: 2572-4 (1993) BindingDB Entry DOI: 10.7270/Q27H1K62 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Displacement of [3H]- diprenorphine from mu-W318A-receptor expressed in HEK 293 cells | J Med Chem 44: 857-62 (2001) BindingDB Entry DOI: 10.7270/Q27H1K9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (MOUSE) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Displacement of [3H]- diprenorphine from delta receptor expressed in HEK 293 cells | J Med Chem 44: 857-62 (2001) BindingDB Entry DOI: 10.7270/Q27H1K9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (GUINEA PIG) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 10.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kitasato University Curated by ChEMBL | Assay Description Displacement of [3H]DAMGO from Hartley guinea pig mu opioid receptor by liquid scintillation counter | Bioorg Med Chem 17: 5983-8 (2009) Article DOI: 10.1016/j.bmc.2009.06.067 BindingDB Entry DOI: 10.7270/Q2154H3Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (GUINEA PIG) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description selective binding affinity against mu opioid receptor, using [3H]DAMGO as radioligand | J Med Chem 36: 2572-4 (1993) BindingDB Entry DOI: 10.7270/Q27H1K62 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (MOUSE) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 from mouse brain membranes. | J Med Chem 40: 3064-70 (1997) Article DOI: 10.1021/jm970283e BindingDB Entry DOI: 10.7270/Q27D2T7R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description The compound tested for agonistic activity against Opioid receptor mu 1 using [3H]- DAMGO as the radioligand. | J Med Chem 40: 1720-5 (1997) Article DOI: 10.1021/jm9700880 BindingDB Entry DOI: 10.7270/Q2FB53M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (MOUSE) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 46.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Displacement of [3H]- diprenorphine from delta-W284E-receptor expressed in HEK 293 cells | J Med Chem 44: 857-62 (2001) BindingDB Entry DOI: 10.7270/Q27H1K9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Rattus norvegicus (rat)) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Displacement of [3H]diprenorphine from k-Y312A-receptor expressed in HEK 293 cells | J Med Chem 44: 857-62 (2001) BindingDB Entry DOI: 10.7270/Q27H1K9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 88.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Displacement of [3H]- diprenorphine from mu-receptor expressed in HEK 293 cells | J Med Chem 44: 857-62 (2001) BindingDB Entry DOI: 10.7270/Q27H1K9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 154 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Displacement of [3H]- diprenorphine from mu-K303E-receptor expressed in HEK 293 cells | J Med Chem 44: 857-62 (2001) BindingDB Entry DOI: 10.7270/Q27H1K9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Rattus norvegicus (rat)) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 292 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Displacement of [3H]diprenorphine from k-E297A-receptor expressed in HEK 293 cells | J Med Chem 44: 857-62 (2001) BindingDB Entry DOI: 10.7270/Q27H1K9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Rattus norvegicus (rat)) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 488 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Displacement of [3H]diprenorphine from opioid receptor kappa 1 expressed in HEK 293 cells | J Med Chem 44: 857-62 (2001) BindingDB Entry DOI: 10.7270/Q27H1K9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 588 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kitasato University Curated by ChEMBL | Assay Description Displacement of [3H]U69493 from Hartley guinea pig kappa opioid receptor by liquid scintillation counter | Bioorg Med Chem 17: 5983-8 (2009) Article DOI: 10.1016/j.bmc.2009.06.067 BindingDB Entry DOI: 10.7270/Q2154H3Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 588 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description selective binding affinity against kappa opioid receptor, using [3H]U-69593 as radioligand | J Med Chem 36: 2572-4 (1993) BindingDB Entry DOI: 10.7270/Q27H1K62 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description The compound tested for agonistic activity against Opioid receptor kappa 1 as the [3H]- U-69,594 radioligand. | J Med Chem 40: 1720-5 (1997) Article DOI: 10.1021/jm9700880 BindingDB Entry DOI: 10.7270/Q2FB53M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Mus musculus (Mouse)) | BDBM50297170 (7-(2'-spiroindanyl)oxymorphone | 7-(Spiroindano)Ox...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of [3H]-U-69,593 binding to Opioid receptor kappa 1 from mouse brain membranes. | J Med Chem 40: 3064-70 (1997) Article DOI: 10.1021/jm970283e BindingDB Entry DOI: 10.7270/Q27D2T7R | |||||||||||
More data for this Ligand-Target Pair |