BindingDB PrimarySearch

BDBM50297447 3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacrylamide::CHEMBL564382::ST-2887

SMILES: ONC(=O)\C=C\c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12

InChI Key: InChIKey=WOXWAGCBPDSRPN-SDNWHVSQSA-N

Data: 11 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50297447
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50297447 (3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sigma-Tau Research and Development Curated by ChEMBL					Assay Description Inhibition of human HDAC1 by fluroimetry				Bioorg Med Chem Lett 19: 2840-3 (2009) Checked by Author Article DOI: 10.1016/j.bmcl.2009.03.101 BindingDB Entry DOI: 10.7270/Q2PN95PT
Sigma-Tau Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50297447 (3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sigma-Tau Research and Development Curated by ChEMBL					Assay Description Inhibition of human HDAC2 by fluroimetry				Bioorg Med Chem Lett 19: 2840-3 (2009) Checked by Author Article DOI: 10.1016/j.bmcl.2009.03.101 BindingDB Entry DOI: 10.7270/Q2PN95PT
Sigma-Tau Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 3 (Homo sapiens (Human))	BDBM50297447 (3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
Sigma-Tau Research and Development Curated by ChEMBL					Assay Description Inhibition of human HDAC3 by fluroimetry				Bioorg Med Chem Lett 19: 2840-3 (2009) Checked by Author Article DOI: 10.1016/j.bmcl.2009.03.101 BindingDB Entry DOI: 10.7270/Q2PN95PT
Sigma-Tau Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 4 (Homo sapiens (Human))	BDBM50297447 (3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sigma-Tau Research and Development Curated by ChEMBL					Assay Description Inhibition of human HDAC4 by fluroimetry				Bioorg Med Chem Lett 19: 2840-3 (2009) Checked by Author Article DOI: 10.1016/j.bmcl.2009.03.101 BindingDB Entry DOI: 10.7270/Q2PN95PT
Sigma-Tau Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 5 (Homo sapiens (Human))	BDBM50297447 (3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sigma-Tau Research and Development Curated by ChEMBL					Assay Description Inhibition of human HDAC5 by fluroimetry				Bioorg Med Chem Lett 19: 2840-3 (2009) Checked by Author Article DOI: 10.1016/j.bmcl.2009.03.101 BindingDB Entry DOI: 10.7270/Q2PN95PT
Sigma-Tau Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 11 (Homo sapiens (Human))	BDBM50297447 (3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Sigma-Tau Research and Development Curated by ChEMBL					Assay Description Inhibition of human HDAC11 by fluroimetry				Bioorg Med Chem Lett 19: 2840-3 (2009) Checked by Author Article DOI: 10.1016/j.bmcl.2009.03.101 BindingDB Entry DOI: 10.7270/Q2PN95PT
Sigma-Tau Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 7 (Homo sapiens (Human))	BDBM50297447 (3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sigma-Tau Research and Development Curated by ChEMBL					Assay Description Inhibition of human HDAC7 by fluroimetry				Bioorg Med Chem Lett 19: 2840-3 (2009) Checked by Author Article DOI: 10.1016/j.bmcl.2009.03.101 BindingDB Entry DOI: 10.7270/Q2PN95PT
Sigma-Tau Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50297447 (3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
Sigma-Tau Research and Development Curated by ChEMBL					Assay Description Inhibition of human HDAC8 by fluroimetry				Bioorg Med Chem Lett 19: 2840-3 (2009) Checked by Author Article DOI: 10.1016/j.bmcl.2009.03.101 BindingDB Entry DOI: 10.7270/Q2PN95PT
Sigma-Tau Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 9 (Homo sapiens (Human))	BDBM50297447 (3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sigma-Tau Research and Development Curated by ChEMBL					Assay Description Inhibition of human HDAC9 by fluroimetry				Bioorg Med Chem Lett 19: 2840-3 (2009) Checked by Author Article DOI: 10.1016/j.bmcl.2009.03.101 BindingDB Entry DOI: 10.7270/Q2PN95PT
Sigma-Tau Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 10 (Homo sapiens (Human))	BDBM50297447 (3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sigma-Tau Research and Development Curated by ChEMBL					Assay Description Inhibition of human HDAC10 by fluroimetry				Bioorg Med Chem Lett 19: 2840-3 (2009) Checked by Author Article DOI: 10.1016/j.bmcl.2009.03.101 BindingDB Entry DOI: 10.7270/Q2PN95PT
Sigma-Tau Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50297447 (3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sigma-Tau Research and Development Curated by ChEMBL					Assay Description Inhibition of human HDAC6 by fluroimetry				Bioorg Med Chem Lett 19: 2840-3 (2009) Checked by Author Article DOI: 10.1016/j.bmcl.2009.03.101 BindingDB Entry DOI: 10.7270/Q2PN95PT
Sigma-Tau Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair