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BDBM50297481 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-2-oxoindoline-4-carbonitrile::CHEMBL554276

SMILES: Fc1cc(CN2C(=O)C(N=O)c3c2cccc3C#N)c2OCOCc2c1

InChI Key: InChIKey=OVCPFCXDWPXDSJ-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50297481   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50297481
PNG
(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Show SMILES Fc1cc(CN2C(=O)C(N=O)c3c2cccc3C#N)c2OCOCc2c1
Show InChI InChI=1S/C18H12FN3O4/c19-13-4-11(17-12(5-13)8-25-9-26-17)7-22-14-3-1-2-10(6-20)15(14)16(21-24)18(22)23/h1-5,16H,7-9H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
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Patents


Similars

Article
PubMed
2.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of JNK3 by spectrophotometric coupled enzyme assay


Bioorg Med Chem Lett 19: 2891-5 (2009)

More data for this
Ligand-Target Pair