BDBM50297800 6-(4-fluorophenyl)-4-(4-methoxybenzyl)-2-(2-morpholinoethylamino)pyrido[2,3-b]pyrazin-3(4H)-one::CHEMBL556514

SMILES: COc1ccc(Cn2c3nc(ccc3nc(NCCN3CCOCC3)c2=O)-c2ccc(F)cc2)cc1

InChI Key: InChIKey=FNHUFWBCAUYKDS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50297800   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50297800 (6-(4-fluorophenyl)-4-(4-methoxybenzyl)-2-(2-morpho...) Show SMILES COc1ccc(Cn2c3nc(ccc3nc(NCCN3CCOCC3)c2=O)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C27H28FN5O3/c1-35-22-8-2-19(3-9-22)18-33-26-24(11-10-23(31-26)20-4-6-21(28)7-5-20)30-25(27(33)34)29-12-13-32-14-16-36-17-15-32/h2-11H,12-18H2,1H3,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PDE5 (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-010-9523-y BindingDB Entry DOI: 10.7270/Q2JW8HS3
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50297800 (6-(4-fluorophenyl)-4-(4-methoxybenzyl)-2-(2-morpho...) Show SMILES COc1ccc(Cn2c3nc(ccc3nc(NCCN3CCOCC3)c2=O)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C27H28FN5O3/c1-35-22-8-2-19(3-9-22)18-33-26-24(11-10-23(31-26)20-4-6-21(28)7-5-20)30-25(27(33)34)29-12-13-32-14-16-36-17-15-32/h2-11H,12-18H2,1H3,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE5				Bioorg Med Chem Lett 19: 4088-91 (2009) Article DOI: 10.1016/j.bmcl.2009.06.012 BindingDB Entry DOI: 10.7270/Q23R0SXR
					More data for this Ligand-Target Pair