BDBM50297807 4-(cyclohexylmethyl)-6-(4-fluorophenyl)-2-((tetrahydro-2H-pyran-4-yl)methylamino)pyrido[2,3-b]pyrazin-3(4H)-one::CHEMBL557467
SMILES: Fc1ccc(cc1)-c1ccc2nc(NCC3CCOCC3)c(=O)n(CC3CCCCC3)c2n1
InChI Key: InChIKey=CNWRBRXWZLSBCF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50297807 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50297807
(4-(cyclohexylmethyl)-6-(4-fluorophenyl)-2-((tetrah...)Show SMILES Fc1ccc(cc1)-c1ccc2nc(NCC3CCOCC3)c(=O)n(CC3CCCCC3)c2n1 Show InChI InChI=1S/C26H31FN4O2/c27-21-8-6-20(7-9-21)22-10-11-23-25(30-22)31(17-19-4-2-1-3-5-19)26(32)24(29-23)28-16-18-12-14-33-15-13-18/h6-11,18-19H,1-5,12-17H2,(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of PDE5 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-010-9523-y BindingDB Entry DOI: 10.7270/Q2JW8HS3 |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50297807
(4-(cyclohexylmethyl)-6-(4-fluorophenyl)-2-((tetrah...)Show SMILES Fc1ccc(cc1)-c1ccc2nc(NCC3CCOCC3)c(=O)n(CC3CCCCC3)c2n1 Show InChI InChI=1S/C26H31FN4O2/c27-21-8-6-20(7-9-21)22-10-11-23-25(30-22)31(17-19-4-2-1-3-5-19)26(32)24(29-23)28-16-18-12-14-33-15-13-18/h6-11,18-19H,1-5,12-17H2,(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of PDE5 |
Bioorg Med Chem Lett 19: 4088-91 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.012 BindingDB Entry DOI: 10.7270/Q23R0SXR |
More data for this Ligand-Target Pair | |