BDBM50297813 6-(4-fluorophenyl)-4-(2-propoxyethyl)-2-((tetrahydro-2H-pyran-4-yl)methylamino)pyrido[2,3-b]pyrazin-3(4H)-one::CHEMBL558466

SMILES: CCCOCCn1c2nc(ccc2nc(NCC2CCOCC2)c1=O)-c1ccc(F)cc1

InChI Key: InChIKey=UAMMPZAQBXSNGC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50297813   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50297813 (6-(4-fluorophenyl)-4-(2-propoxyethyl)-2-((tetrahyd...) Show SMILES CCCOCCn1c2nc(ccc2nc(NCC2CCOCC2)c1=O)-c1ccc(F)cc1 Show InChI InChI=1S/C24H29FN4O3/c1-2-12-31-15-11-29-23-21(8-7-20(28-23)18-3-5-19(25)6-4-18)27-22(24(29)30)26-16-17-9-13-32-14-10-17/h3-8,17H,2,9-16H2,1H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PDE5 (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-010-9523-y BindingDB Entry DOI: 10.7270/Q2JW8HS3
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50297813 (6-(4-fluorophenyl)-4-(2-propoxyethyl)-2-((tetrahyd...) Show SMILES CCCOCCn1c2nc(ccc2nc(NCC2CCOCC2)c1=O)-c1ccc(F)cc1 Show InChI InChI=1S/C24H29FN4O3/c1-2-12-31-15-11-29-23-21(8-7-20(28-23)18-3-5-19(25)6-4-18)27-22(24(29)30)26-16-17-9-13-32-14-10-17/h3-8,17H,2,9-16H2,1H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE5				Bioorg Med Chem Lett 19: 4088-91 (2009) Article DOI: 10.1016/j.bmcl.2009.06.012 BindingDB Entry DOI: 10.7270/Q23R0SXR
					More data for this Ligand-Target Pair