BindingDB PrimarySearch

BDBM50297825 5-(2-methyl-5-(3-(trifluoromethyl)phenylcarbamoyl)phenylamino)nicotinamide::5-[(2-Methyl-5-{[3- (trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide (1)::5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide::CHEMBL552425

SMILES: Cc1ccc(cc1Nc1cncc(c1)C(N)=O)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key: InChIKey=SAAYRHKJHDIDPH-UHFFFAOYSA-N

Data: 5 IC50 2 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50297825
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Discoidin domain-containing receptor 2 (Homo sapiens (Human))	BDBM50297825 (5-(2-methyl-5-(3-(trifluoromethyl)phenylcarbamoyl)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Dana-Farber Cancer Institute					Assay Description The enzymatic activities DDR2 were tested in LanthaScreen binding assays. The protocol is available from Life Technologies.				ACS Chem Biol 10: 2687-96 (2015) Article DOI: 10.1021/acschembio.5b00655 BindingDB Entry DOI: 10.7270/Q2SX6BZ1
Dana-Farber Cancer Institute					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50297825 (5-(2-methyl-5-(3-(trifluoromethyl)phenylcarbamoyl)...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	753	n/a	n/a	n/a	n/a	n/a	n/a
Dana-Farber Cancer Institute					Assay Description The enzymatic activities DDR2 were tested in LanthaScreen binding assays. The protocol is available from Life Technologies.				ACS Chem Biol 10: 2687-96 (2015) Article DOI: 10.1021/acschembio.5b00655 BindingDB Entry DOI: 10.7270/Q2SX6BZ1
Dana-Farber Cancer Institute					More data for this Ligand-Target Pair
Ephrin type-B receptor 2 (Homo sapiens (Human))	BDBM50297825 (5-(2-methyl-5-(3-(trifluoromethyl)phenylcarbamoyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of EphB2				Bioorg Med Chem Lett 19: 4467-70 (2009) Article DOI: 10.1016/j.bmcl.2009.05.029 BindingDB Entry DOI: 10.7270/Q2V69JN0
Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human))	BDBM50297825 (5-(2-methyl-5-(3-(trifluoromethyl)phenylcarbamoyl)...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of FLAG-tagged DDR1 in human HEK293 cells assessed as reduction in collagen-1-induced DDR1 phosphorylation incubated for 18 hrs by ELISA				ACS Med Chem Lett 11: 29-33 (2020) Article DOI: 10.1021/acsmedchemlett.9b00382
Vanderbilt University Curated by ChEMBL					More data for this Ligand-Target Pair
Discoidin domain-containing receptor 2 (Homo sapiens (Human))	BDBM50297825 (5-(2-methyl-5-(3-(trifluoromethyl)phenylcarbamoyl)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of kinase tracer 178 binding to recombinant human GST-tagged DDR2 (427-855 residues) expressed in baculovirus expression system incubated ...				ACS Med Chem Lett 11: 29-33 (2020) Article DOI: 10.1021/acsmedchemlett.9b00382
Vanderbilt University Curated by ChEMBL					More data for this Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human))	BDBM50297825 (5-(2-methyl-5-(3-(trifluoromethyl)phenylcarbamoyl)...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of kinase tracer 178 binding to recombinant human GST-tagged DDR1 expressed in baculovirus expression system incubated for 60 mins by TR-F...				ACS Med Chem Lett 11: 29-33 (2020) Article DOI: 10.1021/acsmedchemlett.9b00382
Vanderbilt University Curated by ChEMBL					More data for this Ligand-Target Pair
Ephrin type-B receptor 2 (Homo sapiens (Human))	BDBM50297825 (5-(2-methyl-5-(3-(trifluoromethyl)phenylcarbamoyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of ephrinB1-induced autophosphorylation of EphB2 expressed in human U87 cells after 1 hr by western blot analysis				Bioorg Med Chem Lett 19: 4467-70 (2009) Article DOI: 10.1016/j.bmcl.2009.05.029 BindingDB Entry DOI: 10.7270/Q2V69JN0
Institute Curated by ChEMBL					More data for this Ligand-Target Pair