null

SMILES: C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCNC(=O)C2)cc1Cl

InChI Key: InChIKey=KDBHWYQEQOHRMN-OAHLLOKOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50297981   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50297981 ((R)-3-(1-(2-chloro-4-((3-oxopiperazin-1-yl)methyl)...) Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCNC(=O)C2)cc1Cl |r| Show InChI InChI=1S/C25H24ClN5O3S/c1-15(17-6-5-16(10-18(17)26)13-30-9-7-28-23(32)14-30)34-20-11-21(35-24(20)25(27)33)19-12-29-22-4-2-3-8-31(19)22/h2-6,8,10-12,15H,7,9,13-14H2,1H3,(H2,27,33)(H,28,32)/t15-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of PLK1				Bioorg Med Chem Lett 19: 4673-8 (2009) Article DOI: 10.1016/j.bmcl.2009.06.084 BindingDB Entry DOI: 10.7270/Q22R3RQG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50297981 ((R)-3-(1-(2-chloro-4-((3-oxopiperazin-1-yl)methyl)...) Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCNC(=O)C2)cc1Cl |r| Show InChI InChI=1S/C25H24ClN5O3S/c1-15(17-6-5-16(10-18(17)26)13-30-9-7-28-23(32)14-30)34-20-11-21(35-24(20)25(27)33)19-12-29-22-4-2-3-8-31(19)22/h2-6,8,10-12,15H,7,9,13-14H2,1H3,(H2,27,33)(H,28,32)/t15-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.70E+6	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of PLK1-mediated mitosis in human HeLaS3 cells after 18 hrs				Bioorg Med Chem Lett 19: 4673-8 (2009) Article DOI: 10.1016/j.bmcl.2009.06.084 BindingDB Entry DOI: 10.7270/Q22R3RQG
					More data for this Ligand-Target Pair