BindingDB PrimarySearch

null

SMILES: Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12

InChI Key: InChIKey=UQPMANVRZYYQMD-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50298223
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Aurora kinase B (Homo sapiens (Human))	BDBM50298223 (CGP-57380 \| CHEMBL1240885 \| CHEMBL576817 \| N-(4-fl...) Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of Aurora B in the presence of 20uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50298223 (CGP-57380 \| CHEMBL1240885 \| CHEMBL576817 \| N-(4-fl...) Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	880	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of Mnk2 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay				Eur J Med Chem 95: 116-26 (2015) Article DOI: 10.1016/j.ejmech.2015.03.032 BindingDB Entry DOI: 10.7270/Q28917K3
University of South Australia Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50298223 (CGP-57380 \| CHEMBL1240885 \| CHEMBL576817 \| N-(4-fl...) Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.01E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of Mnk1 (unknown origin) pre-incubated for 10 mins before eIF4E peptide substrate addition by ADP-Glo kinase assay				Eur J Med Chem 95: 116-26 (2015) Article DOI: 10.1016/j.ejmech.2015.03.032 BindingDB Entry DOI: 10.7270/Q28917K3
University of South Australia Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50298223 (CGP-57380 \| CHEMBL1240885 \| CHEMBL576817 \| N-(4-fl...) Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
Spanish National Cancer Research Centre (CNIO) Curated by ChEMBL					Assay Description Inhibition of MNK1				J Med Chem 53: 6618-28 (2010) Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50298223 (CGP-57380 \| CHEMBL1240885 \| CHEMBL576817 \| N-(4-fl...) Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Spanish National Cancer Research Centre (CNIO) Curated by ChEMBL					Assay Description Inhibition of MNK2				J Med Chem 53: 6618-28 (2010) Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50298223 (CGP-57380 \| CHEMBL1240885 \| CHEMBL576817 \| N-(4-fl...) Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Spanish National Cancer Research Centre (CNIO) Curated by ChEMBL					Assay Description Inhibition of SGK1				J Med Chem 53: 6618-28 (2010) Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50298223 (CGP-57380 \| CHEMBL1240885 \| CHEMBL576817 \| N-(4-fl...) Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of SGK1 in the presence of 20uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM50298223 (CGP-57380 \| CHEMBL1240885 \| CHEMBL576817 \| N-(4-fl...) Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of CK1delta in the presence of 20uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase BRSK2 (Homo sapiens (Human))	BDBM50298223 (CGP-57380 \| CHEMBL1240885 \| CHEMBL576817 \| N-(4-fl...) Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12 Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of BRSK2 in the presence of 50uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50298223 (CGP-57380 \| CHEMBL1240885 \| CHEMBL576817 \| N-(4-fl...) Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of MNK2 in the presence of 50uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50298223 (CGP-57380 \| CHEMBL1240885 \| CHEMBL576817 \| N-(4-fl...) Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of MNK1 in the presence of 50uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 3 (Homo sapiens (Human))	BDBM50298223 (CGP-57380 \| CHEMBL1240885 \| CHEMBL576817 \| N-(4-fl...) Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of DYRK3 in the presence of 5uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM50298223 (CGP-57380 \| CHEMBL1240885 \| CHEMBL576817 \| N-(4-fl...) Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of Lck in the presence of 50uM ATP				Biochem J 408: 297-315 (2007) Article DOI: 10.1042/BJ20070797 BindingDB Entry DOI: 10.7270/Q27082B4
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase (Homo sapiens (Human))	BDBM50298223 (CGP-57380 \| CHEMBL1240885 \| CHEMBL576817 \| N-(4-fl...) Show SMILES Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Weill Cornell Medical College Curated by ChEMBL					Assay Description Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay				Bioorg Med Chem Lett 21: 4108-14 (2011) Article DOI: 10.1016/j.bmcl.2011.04.149 BindingDB Entry DOI: 10.7270/Q2KK9C4H
Weill Cornell Medical College Curated by ChEMBL					More data for this Ligand-Target Pair