BDBM50299058 (+/-)-2-[2-(Biphenyl-4-sulfonyl)phenyl]N-hydroxy-propionamide::CHEMBL574605

SMILES: CC(C(=O)NO)c1ccccc1S(=O)(=O)c1ccc(cc1)-c1ccccc1

InChI Key: InChIKey=CPUBMGYGVNFLPZ-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50299058   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Matrix metalloproteinase-14 (MMP14) (Homo sapiens (Human))	BDBM50299058 ((+/-)-2-[2-(Biphenyl-4-sulfonyl)phenyl]N-hydroxy-p...) Show SMILES CC(C(=O)NO)c1ccccc1S(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H19NO4S/c1-15(21(23)22-24)19-9-5-6-10-20(19)27(25,26)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-15,24H,1H3,(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of human recombinant pro-MMP14 catalytic domain after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50299058 ((+/-)-2-[2-(Biphenyl-4-sulfonyl)phenyl]N-hydroxy-p...) Show SMILES CC(C(=O)NO)c1ccccc1S(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H19NO4S/c1-15(21(23)22-24)19-9-5-6-10-20(19)27(25,26)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-15,24H,1H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of para-aminophenylmercuric acetate-activated human recombinant pro-MMP9 catalytic domain after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12) (Homo sapiens (Human))	BDBM50299058 ((+/-)-2-[2-(Biphenyl-4-sulfonyl)phenyl]N-hydroxy-p...) Show SMILES CC(C(=O)NO)c1ccccc1S(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H19NO4S/c1-15(21(23)22-24)19-9-5-6-10-20(19)27(25,26)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-15,24H,1H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of autoactivated human pro-MMP12 after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50299058 ((+/-)-2-[2-(Biphenyl-4-sulfonyl)phenyl]N-hydroxy-p...) Show SMILES CC(C(=O)NO)c1ccccc1S(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H19NO4S/c1-15(21(23)22-24)19-9-5-6-10-20(19)27(25,26)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-15,24H,1H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of para-aminophenylmercuric acetate-activated human recombinant pro-MMP2 catalytic domain after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50299058 ((+/-)-2-[2-(Biphenyl-4-sulfonyl)phenyl]N-hydroxy-p...) Show SMILES CC(C(=O)NO)c1ccccc1S(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H19NO4S/c1-15(21(23)22-24)19-9-5-6-10-20(19)27(25,26)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-15,24H,1H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of para-aminophenylmercuric acetate-activated human pro-MMP1 after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50299058 ((+/-)-2-[2-(Biphenyl-4-sulfonyl)phenyl]N-hydroxy-p...) Show SMILES CC(C(=O)NO)c1ccccc1S(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H19NO4S/c1-15(21(23)22-24)19-9-5-6-10-20(19)27(25,26)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-15,24H,1H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of para-aminophenylmercuric acetate-activated human pro-MMP8 after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair
Matrix metalloproteinase 16 (Homo sapiens (Human))	BDBM50299058 ((+/-)-2-[2-(Biphenyl-4-sulfonyl)phenyl]N-hydroxy-p...) Show SMILES CC(C(=O)NO)c1ccccc1S(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H19NO4S/c1-15(21(23)22-24)19-9-5-6-10-20(19)27(25,26)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-15,24H,1H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of human recombinant pro-MMP16 catalytic domain after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50299058 ((+/-)-2-[2-(Biphenyl-4-sulfonyl)phenyl]N-hydroxy-p...) Show SMILES CC(C(=O)NO)c1ccccc1S(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H19NO4S/c1-15(21(23)22-24)19-9-5-6-10-20(19)27(25,26)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-15,24H,1H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of trypsin activated human pro-MMP3 after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM50299058 ((+/-)-2-[2-(Biphenyl-4-sulfonyl)phenyl]N-hydroxy-p...) Show SMILES CC(C(=O)NO)c1ccccc1S(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H19NO4S/c1-15(21(23)22-24)19-9-5-6-10-20(19)27(25,26)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-15,24H,1H3,(H,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of para-aminophenylmercuric acetate-activated human pro-MMP13 after 4 hrs by fluorimetry				J Med Chem 52: 6347-61 (2009) Article DOI: 10.1021/jm900335a BindingDB Entry DOI: 10.7270/Q2HQ3ZZS
					More data for this Ligand-Target Pair