BindingDB PrimarySearch

BDBM50299083 (S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2-yl)benzofuran::CHEMBL574613

SMILES: CC[S@](=O)c1ccc(cc1)-c1coc2ccc(cc12)-c1ccc(C)o1

InChI Key: InChIKey=NCGGCRHITOMNJS-VWLOTQADSA-N

Data: 23 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50299083
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged CHK1 by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of c-Kit by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of human recombinant GSK3-beta				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of C-terminal 6xHis-tagged CDK1 by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of C-terminal 6xHis-tagged CDK2 by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent-like kinase 5 (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of CDK5 by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of N-terminal FLAG-tagged p38alpha by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of N-terminal FLAG-tagged JNK1 by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 1 (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of C-terminal FLAG-tagged MEKK1 by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of Src by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of Lck by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of N-terminal FLAG-tagged VEGFR2 by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of C-terminal FLAG-tagged IKK-beta by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of N-terminal FLAG-tagged PKCtheta by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Casein kinase I isoform delta (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of N-terminal FLAG-tagged CK1delta by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of N-terminal peptide-tagged EGFR cytoplasmic domain by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of N-terminal peptide-tagged ERBB2 cytoplasmic domain by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of FGFR3 by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of PDGFRalpha by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of PDGFRbeta by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of TIE2 by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of c-Met by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50299083 ((S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of insulin receptor by [gamma-33-P]ATP based assay				J Med Chem 52: 6270-86 (2009) Article DOI: 10.1021/jm900647e BindingDB Entry DOI: 10.7270/Q2CZ377V
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair