null

SMILES: O=C(Nc1cccnc1)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1

InChI Key: InChIKey=QDVKRHSEGADNGG-SFHVURJKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50299144   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2 (Homo sapiens (Human))	BDBM50299144 ((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...) Show SMILES O=C(Nc1cccnc1)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1 |r| Show InChI InChI=1S/C22H23N9O/c32-21(24-15-4-1-9-23-13-15)18-6-2-10-30(18)22-26-20(17-5-3-11-31(17)29-22)25-19-12-16(27-28-19)14-7-8-14/h1,3-5,9,11-14,18H,2,6-8,10H2,(H,24,32)(H2,25,26,27,28,29)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	577	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Inhibition of CDK2/Cyclin E after 60 mins by fluorescence electrophoresis				J Med Chem 52: 7360-3 (2009) Article DOI: 10.1021/jm900786r BindingDB Entry DOI: 10.7270/Q2P27022
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50299144 ((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...) Show SMILES O=C(Nc1cccnc1)[C@@H]1CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1 |r| Show InChI InChI=1S/C22H23N9O/c32-21(24-15-4-1-9-23-13-15)18-6-2-10-30(18)22-26-20(17-5-3-11-31(17)29-22)25-19-12-16(27-28-19)14-7-8-14/h1,3-5,9,11-14,18H,2,6-8,10H2,(H,24,32)(H2,25,26,27,28,29)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Inhibition of IGF1R after 60 mins by fluorescence electrophoresis				J Med Chem 52: 7360-3 (2009) Article DOI: 10.1021/jm900786r BindingDB Entry DOI: 10.7270/Q2P27022
					More data for this Ligand-Target Pair