BDBM50299363 CHEMBL575555::N2-benzyl-6-(piperazin-1-yl)-N4-(pyridin-4-yl)-1,3,5-triazine-2,4-diamine

SMILES: C(Nc1nc(Nc2ccncc2)nc(n1)N1CCNCC1)c1ccccc1

InChI Key: InChIKey=ISYXVFFEJOZHOV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50299363   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50299363 (CHEMBL575555 | N2-benzyl-6-(piperazin-1-yl)-N4-(py...) Show SMILES C(Nc1nc(Nc2ccncc2)nc(n1)N1CCNCC1)c1ccccc1 Show InChI InChI=1S/C19H22N8/c1-2-4-15(5-3-1)14-22-17-24-18(23-16-6-8-20-9-7-16)26-19(25-17)27-12-10-21-11-13-27/h1-9,21H,10-14H2,(H2,20,22,23,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK1 by IMAP assay				Bioorg Med Chem Lett 19: 6027-31 (2009) Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P
					More data for this Ligand-Target Pair