BDBM50299371 CHEMBL573152::N2-(2,3-dihydro-1H-inden-2-yl)-6-(4-methylpiperazin-1-yl)-N4-(pyridin-4-yl)-1,3,5-triazine-2,4-diamine
SMILES: CN1CCN(CC1)c1nc(NC2Cc3ccccc3C2)nc(Nc2ccncc2)n1
InChI Key: InChIKey=JEBRKVCPEQRUBJ-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM50299371 (CHEMBL573152 | N2-(2,3-dihydro-1H-inden-2-yl)-6-(4...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 305 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of ROCK1 by IMAP assay | Bioorg Med Chem Lett 19: 6027-31 (2009) Article DOI: 10.1016/j.bmcl.2009.09.046 BindingDB Entry DOI: 10.7270/Q2668D7P | |||||||||||
More data for this Ligand-Target Pair |