Found 8 hits for monomerid = 50299461 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human)) | BDBM50299461
((S)-7-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-...)Show SMILES OC(=O)C(=O)Nc1sc2[C@H](COC3=NS(=O)(=O)c4ccccc34)OCCc2c1C(O)=O |r,t:12| Show InChI InChI=1S/C18H14N2O9S2/c21-14(18(24)25)19-16-12(17(22)23)9-5-6-28-10(13(9)30-16)7-29-15-8-3-1-2-4-11(8)31(26,27)20-15/h1-4,10H,5-7H2,(H,19,21)(H,22,23)(H,24,25)/t10-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
| Article PubMed
| 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Miami
Curated by ChEMBL
| Assay Description Inhibition of PTPN2 |
J Med Chem 52: 6649-59 (2009)
Article DOI: 10.1021/jm9008899 BindingDB Entry DOI: 10.7270/Q29023T5 |
More data for this Ligand-Target Pair | |
Protein-tyrosine phosphatase 1B
(Homo sapiens (Human)) | BDBM50299461
((S)-7-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-...)Show SMILES OC(=O)C(=O)Nc1sc2[C@H](COC3=NS(=O)(=O)c4ccccc34)OCCc2c1C(O)=O |r,t:12| Show InChI InChI=1S/C18H14N2O9S2/c21-14(18(24)25)19-16-12(17(22)23)9-5-6-28-10(13(9)30-16)7-29-15-8-3-1-2-4-11(8)31(26,27)20-15/h1-4,10H,5-7H2,(H,19,21)(H,22,23)(H,24,25)/t10-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
| MMDB PDB Article PubMed
| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Miami
Curated by ChEMBL
| Assay Description Inhibition of PTPN1 |
J Med Chem 52: 6649-59 (2009)
Article DOI: 10.1021/jm9008899 BindingDB Entry DOI: 10.7270/Q29023T5 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Receptor-type tyrosine-protein phosphatase beta (PTPβ)
(Homo sapiens (Human)) | BDBM50299461
((S)-7-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-...)Show SMILES OC(=O)C(=O)Nc1sc2[C@H](COC3=NS(=O)(=O)c4ccccc34)OCCc2c1C(O)=O |r,t:12| Show InChI InChI=1S/C18H14N2O9S2/c21-14(18(24)25)19-16-12(17(22)23)9-5-6-28-10(13(9)30-16)7-29-15-8-3-1-2-4-11(8)31(26,27)20-15/h1-4,10H,5-7H2,(H,19,21)(H,22,23)(H,24,25)/t10-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
| Article PubMed
| 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Miami
Curated by ChEMBL
| Assay Description Inhibition of PTPRB |
J Med Chem 52: 6649-59 (2009)
Article DOI: 10.1021/jm9008899 BindingDB Entry DOI: 10.7270/Q29023T5 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase F (LAR)
(Homo sapiens (Human)) | BDBM50299461
((S)-7-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-...)Show SMILES OC(=O)C(=O)Nc1sc2[C@H](COC3=NS(=O)(=O)c4ccccc34)OCCc2c1C(O)=O |r,t:12| Show InChI InChI=1S/C18H14N2O9S2/c21-14(18(24)25)19-16-12(17(22)23)9-5-6-28-10(13(9)30-16)7-29-15-8-3-1-2-4-11(8)31(26,27)20-15/h1-4,10H,5-7H2,(H,19,21)(H,22,23)(H,24,25)/t10-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
| Article PubMed
| 1.76E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Miami
Curated by ChEMBL
| Assay Description Inhibition of PTPRF |
J Med Chem 52: 6649-59 (2009)
Article DOI: 10.1021/jm9008899 BindingDB Entry DOI: 10.7270/Q29023T5 |
More data for this Ligand-Target Pair | |
Protein-tyrosine phosphatase 1C
(Homo sapiens (Human)) | BDBM50299461
((S)-7-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-...)Show SMILES OC(=O)C(=O)Nc1sc2[C@H](COC3=NS(=O)(=O)c4ccccc34)OCCc2c1C(O)=O |r,t:12| Show InChI InChI=1S/C18H14N2O9S2/c21-14(18(24)25)19-16-12(17(22)23)9-5-6-28-10(13(9)30-16)7-29-15-8-3-1-2-4-11(8)31(26,27)20-15/h1-4,10H,5-7H2,(H,19,21)(H,22,23)(H,24,25)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
| Article PubMed
| 2.89E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Miami
Curated by ChEMBL
| Assay Description Inhibition of PTPN6 |
J Med Chem 52: 6649-59 (2009)
Article DOI: 10.1021/jm9008899 BindingDB Entry DOI: 10.7270/Q29023T5 |
More data for this Ligand-Target Pair | |
Leukocyte common antigen
(Homo sapiens (Human)) | BDBM50299461
((S)-7-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-...)Show SMILES OC(=O)C(=O)Nc1sc2[C@H](COC3=NS(=O)(=O)c4ccccc34)OCCc2c1C(O)=O |r,t:12| Show InChI InChI=1S/C18H14N2O9S2/c21-14(18(24)25)19-16-12(17(22)23)9-5-6-28-10(13(9)30-16)7-29-15-8-3-1-2-4-11(8)31(26,27)20-15/h1-4,10H,5-7H2,(H,19,21)(H,22,23)(H,24,25)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
| Article PubMed
| 4.89E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Miami
Curated by ChEMBL
| Assay Description Inhibition of PTPRC |
J Med Chem 52: 6649-59 (2009)
Article DOI: 10.1021/jm9008899 BindingDB Entry DOI: 10.7270/Q29023T5 |
More data for this Ligand-Target Pair | |
Protein-tyrosine phosphatase alpha
(Homo sapiens (Human)) | BDBM50299461
((S)-7-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-...)Show SMILES OC(=O)C(=O)Nc1sc2[C@H](COC3=NS(=O)(=O)c4ccccc34)OCCc2c1C(O)=O |r,t:12| Show InChI InChI=1S/C18H14N2O9S2/c21-14(18(24)25)19-16-12(17(22)23)9-5-6-28-10(13(9)30-16)7-29-15-8-3-1-2-4-11(8)31(26,27)20-15/h1-4,10H,5-7H2,(H,19,21)(H,22,23)(H,24,25)/t10-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
| Article PubMed
| >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Miami
Curated by ChEMBL
| Assay Description Inhibition of PTPRA |
J Med Chem 52: 6649-59 (2009)
Article DOI: 10.1021/jm9008899 BindingDB Entry DOI: 10.7270/Q29023T5 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase epsilon (PTPε)
(Homo sapiens (Human)) | BDBM50299461
((S)-7-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-...)Show SMILES OC(=O)C(=O)Nc1sc2[C@H](COC3=NS(=O)(=O)c4ccccc34)OCCc2c1C(O)=O |r,t:12| Show InChI InChI=1S/C18H14N2O9S2/c21-14(18(24)25)19-16-12(17(22)23)9-5-6-28-10(13(9)30-16)7-29-15-8-3-1-2-4-11(8)31(26,27)20-15/h1-4,10H,5-7H2,(H,19,21)(H,22,23)(H,24,25)/t10-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
| Article PubMed
| >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Miami
Curated by ChEMBL
| Assay Description Inhibition of PTPRE |
J Med Chem 52: 6649-59 (2009)
Article DOI: 10.1021/jm9008899 BindingDB Entry DOI: 10.7270/Q29023T5 |
More data for this Ligand-Target Pair | |