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SMILES: COc1cc(nn1-c1ccc(cc1)C(F)(F)F)[C@@H](C)N[C@H](C)c1cccc(Cl)c1

InChI Key: InChIKey=IGAOIMCWHVGWEL-ZIAGYGMSSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50299682   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50299682
PNG
((1R)-1-(3-chlorophenyl)-N-((1R)-1-(5-methoxy-1-(4-...)
Show SMILES COc1cc(nn1-c1ccc(cc1)C(F)(F)F)[C@@H](C)N[C@H](C)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C21H21ClF3N3O/c1-13(15-5-4-6-17(22)11-15)26-14(2)19-12-20(29-3)28(27-19)18-9-7-16(8-10-18)21(23,24)25/h4-14,26H,1-3H3/t13-,14-/m1/s1
PDB

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antibodypedia
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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 41n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assay

J Med Chem 52: 6535-8 (2009)


Article DOI: 10.1021/jm9012278
BindingDB Entry DOI: 10.7270/Q28052PS
More data for this
Ligand-Target Pair