BDBM50300386 2-(5-bromo-2-(2-methoxy-4-(2-methyl-1H-imidazol-1-yl)phenylamino)pyrimidin-4-ylamino)-N-methylbenzenesulfonamide::CHEMBL574841

SMILES: CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)-n2ccnc2C)ncc1Br

InChI Key: InChIKey=OWTAOUVQYMPSRH-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50300386   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM50300386 (2-(5-bromo-2-(2-methoxy-4-(2-methyl-1H-imidazol-1-...) Show SMILES CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)-n2ccnc2C)ncc1Br Show InChI InChI=1S/C22H22BrN7O3S/c1-14-25-10-11-30(14)15-8-9-17(19(12-15)33-3)28-22-26-13-16(23)21(29-22)27-18-6-4-5-7-20(18)34(31,32)24-2/h4-13,24H,1-3H3,(H2,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
GVK Biosciences Pvt. Ltd. Curated by ChEMBL					Assay Description Inhibition of human GST-fused ZAP-70 expressed in Sf9 cells				Eur J Med Chem 44: 4793-800 (2009) Article DOI: 10.1016/j.ejmech.2009.07.018 BindingDB Entry DOI: 10.7270/Q25X290Z
					More data for this Ligand-Target Pair