BDBM50300425 CHEMBL573028::Methyl 3-(4,5-dichloro-3-oxoisothiazol-2(3H)-yl)propanoate

SMILES: COC(=O)CCn1sc(Cl)c(Cl)c1=O

InChI Key: InChIKey=IEOLCPFVHLQOJV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50300425   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone acetyltransferase PCAF (Homo sapiens (Human))	BDBM50300425 (CHEMBL573028 | Methyl 3-(4,5-dichloro-3-oxoisothia...) Show SMILES COC(=O)CCn1sc(Cl)c(Cl)c1=O Show InChI InChI=1S/C7H7Cl2NO3S/c1-13-4(11)2-3-10-7(12)5(8)6(9)14-10/h2-3H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human recombinant histone acetyltransferase PCAF assessed as CoA-SH activity preincubated for 15 mins by CPM fluorescent assay				Eur J Med Chem 44: 4855-61 (2009) Article DOI: 10.1016/j.ejmech.2009.07.025 BindingDB Entry DOI: 10.7270/Q2XD11RS
					More data for this Ligand-Target Pair