BDBM50300693 CHEMBL575307::N-(5-tert-Butyl-isoxazol-3-yl)-N'-[4-(7-hydroxyimidazo[2,1-b][1,3]benzothiazol-2-yl)phenyl]urea

SMILES: CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(O)ccc32)no1

InChI Key: InChIKey=GREBSQQIJHEOEL-UHFFFAOYSA-N

Data: 1 Kd

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50300693   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50300693 (CHEMBL575307 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-[...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(O)ccc32)no1 Show InChI InChI=1S/C23H21N5O3S/c1-23(2,3)19-11-20(27-31-19)26-21(30)24-14-6-4-13(5-7-14)16-12-28-17-9-8-15(29)10-18(17)32-22(28)25-16/h4-12,29H,1-3H3,(H2,24,26,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by ChEMBL					Assay Description Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay				J Med Chem 52: 7808-16 (2009) Article DOI: 10.1021/jm9007533 BindingDB Entry DOI: 10.7270/Q2319VZ6
					More data for this Ligand-Target Pair