BDBM50300706 CHEMBL584293::N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(3-morphlino-4-yl-propyl)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea

SMILES: CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(CCCN4CCOCC4)ccc32)no1

InChI Key: InChIKey=UMYGVIGBQXDICG-UHFFFAOYSA-N

Data: 1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50300706   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50300706 (CHEMBL584293 | N-(5-tert-Butylisoxazol-3-yl)-N'-{4...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(CCCN4CCOCC4)ccc32)no1 Show InChI InChI=1S/C30H34N6O3S/c1-30(2,3)26-18-27(34-39-26)33-28(37)31-22-9-7-21(8-10-22)23-19-36-24-11-6-20(17-25(24)40-29(36)32-23)5-4-12-35-13-15-38-16-14-35/h6-11,17-19H,4-5,12-16H2,1-3H3,(H2,31,33,34,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by ChEMBL					Assay Description Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay				J Med Chem 52: 7808-16 (2009) Article DOI: 10.1021/jm9007533 BindingDB Entry DOI: 10.7270/Q2319VZ6
					More data for this Ligand-Target Pair