BDBM50300707 CHEMBL581849::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(4-ethylpiperazin-1-ylmethyl)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea

SMILES: CCN1CCN(Cc2ccc3c(c2)sc2nc(cn32)-c2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)CC1

InChI Key: InChIKey=GHQAZOFJLBXOHF-UHFFFAOYSA-N

Data: 1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50300707   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50300707 (CHEMBL581849 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES CCN1CCN(Cc2ccc3c(c2)sc2nc(cn32)-c2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)CC1 Show InChI InChI=1S/C30H35N7O2S/c1-5-35-12-14-36(15-13-35)18-20-6-11-24-25(16-20)40-29-32-23(19-37(24)29)21-7-9-22(10-8-21)31-28(38)33-27-17-26(39-34-27)30(2,3)4/h6-11,16-17,19H,5,12-15,18H2,1-4H3,(H2,31,33,34,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by ChEMBL					Assay Description Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay				J Med Chem 52: 7808-16 (2009) Article DOI: 10.1021/jm9007533 BindingDB Entry DOI: 10.7270/Q2319VZ6
					More data for this Ligand-Target Pair