BDBM50300978 3-(2-(4-hydroxypiperidin-1-yl)-2-oxoethylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one::CHEMBL569264
SMILES: CCCOCCn1c2cc(ncc2nc(NCC(=O)N2CCC(O)CC2)c1=O)-c1ccc(OC)nc1
InChI Key: InChIKey=RNGOEGWXBHOIFX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50300978 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha
(Homo sapiens (Human)) | BDBM50300978
(3-(2-(4-hydroxypiperidin-1-yl)-2-oxoethylamino)-7-...)Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)N2CCC(O)CC2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C25H32N6O5/c1-3-11-36-12-10-31-21-13-19(17-4-5-22(35-2)27-14-17)26-15-20(21)29-24(25(31)34)28-16-23(33)30-8-6-18(32)7-9-30/h4-5,13-15,18,32H,3,6-12,16H2,1-2H3,(H,28,29) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of PDE6 |
Bioorg Med Chem Lett 19: 5209-13 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50300978
(3-(2-(4-hydroxypiperidin-1-yl)-2-oxoethylamino)-7-...)Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)N2CCC(O)CC2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C25H32N6O5/c1-3-11-36-12-10-31-21-13-19(17-4-5-22(35-2)27-14-17)26-15-20(21)29-24(25(31)34)28-16-23(33)30-8-6-18(32)7-9-30/h4-5,13-15,18,32H,3,6-12,16H2,1-2H3,(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of PDE5 |
Bioorg Med Chem Lett 19: 5209-13 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV |
More data for this Ligand-Target Pair | |