BDBM50301009 4-(2,4-dichloro-5-methoxyphenylamino)-7-(5-(morpholinomethyl)pyridin-2-yl)quinoline-3-carbonitrile::CHEMBL584915
SMILES: COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCOCC3)cn2)C#N)c(Cl)cc1Cl
InChI Key: InChIKey=RSLHSUVMGKXAEL-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM50301009 (4-(2,4-dichloro-5-methoxyphenylamino)-7-(5-(morpho...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of human Src expressed in rat fibroblasts assessed as anchorage independent growth after 3 days | Bioorg Med Chem Lett 19: 5071-4 (2009) Article DOI: 10.1016/j.bmcl.2009.07.043 BindingDB Entry DOI: 10.7270/Q27M081R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM50301009 (4-(2,4-dichloro-5-methoxyphenylamino)-7-(5-(morpho...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of Src | Bioorg Med Chem Lett 19: 5071-4 (2009) Article DOI: 10.1016/j.bmcl.2009.07.043 BindingDB Entry DOI: 10.7270/Q27M081R | |||||||||||
More data for this Ligand-Target Pair |