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SMILES: CNCCN1CCC(CC1)c1cc(C)c2nc([nH]c2c1)-c1cccnc1OC

InChI Key: InChIKey=KURQUYFXRUVCIU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50301069   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))		BDBM50301069
PNG
(2-(4-(2-(2-methoxypyridin-3-yl)-4-methyl-1H-benzo[...)
Show SMILES CNCCN1CCC(CC1)c1cc(C)c2nc([nH]c2c1)-c1cccnc1OC
Show InChI InChI=1S/C22H29N5O/c1-15-13-17(16-6-10-27(11-7-16)12-9-23-2)14-19-20(15)26-21(25-19)18-5-4-8-24-22(18)28-3/h4-5,8,13-14,16,23H,6-7,9-12H2,1-3H3,(H,25,26)
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Article
PubMed
n/an/a 0.840n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human CARM1 assessed as inhibition of histone3 methylation

Bioorg Med Chem Lett 19: 5063-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.040
BindingDB Entry DOI: 10.7270/Q2KW5G3W
More data for this
Ligand-Target Pair