BDBM50301159 1-(2-(dimethylamino)ethyl)-3-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl)urea::CHEMBL565814

SMILES: CN(C)CCNC(=O)Nc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1

InChI Key: InChIKey=DPXLCXOTWYKETD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50301159   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50301159 (1-(2-(dimethylamino)ethyl)-3-(4-(2-(pyridin-2-yl)-...) Show SMILES CN(C)CCNC(=O)Nc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1 |(10.72,-21.09,;10.76,-19.56,;9.44,-18.74,;12.11,-18.82,;12.16,-17.27,;10.84,-16.47,;10.88,-14.93,;9.57,-14.13,;12.24,-14.2,;13.55,-15,;14.9,-14.28,;16.21,-15.08,;16.16,-16.61,;17.48,-17.42,;17.43,-18.95,;16.08,-19.68,;14.76,-18.88,;14.81,-17.34,;13.51,-16.54,;18.84,-16.69,;19.31,-15.21,;18.82,-13.74,;20.06,-12.83,;21.31,-13.72,;20.85,-15.21,;21.33,-16.68,;20.07,-17.58,;20.07,-19.12,;18.74,-19.89,;18.74,-21.44,;20.07,-22.21,;21.41,-21.44,;21.41,-19.89,)| Show InChI InChI=1S/C25H27N7O/c1-31(2)15-13-28-25(33)29-17-8-9-18-19(10-12-27-21(18)16-17)23-22-7-5-14-32(22)30-24(23)20-6-3-4-11-26-20/h3-4,6,8-12,16H,5,7,13-15H2,1-2H3,(H2,28,29,33)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of TGFR1				Eur J Med Chem 44: 4259-65 (2009) Article DOI: 10.1016/j.ejmech.2009.07.008 BindingDB Entry DOI: 10.7270/Q2BC3ZM9
					More data for this Ligand-Target Pair