BDBM50301173 3-methoxy-N-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl)propanamide::CHEMBL565645

SMILES: COCCC(=O)Nc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1

InChI Key: InChIKey=XNVUSGWCJPEGQX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50301173   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50301173 (3-methoxy-N-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-py...) Show SMILES COCCC(=O)Nc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1 |(-.85,-11.96,;.5,-12.7,;1.82,-11.9,;3.17,-12.65,;4.49,-11.86,;4.46,-10.31,;5.84,-12.6,;7.16,-11.81,;7.14,-10.27,;8.45,-9.48,;9.79,-10.23,;11.11,-9.43,;12.46,-10.17,;12.49,-11.71,;11.16,-12.51,;9.81,-11.76,;8.5,-12.54,;11.09,-7.89,;9.82,-7,;8.28,-7.02,;7.79,-5.57,;9.02,-4.64,;10.28,-5.53,;11.82,-5.5,;12.32,-6.96,;13.65,-7.72,;13.66,-9.27,;15,-10.03,;16.33,-9.25,;16.32,-7.7,;14.98,-6.94,)| Show InChI InChI=1S/C24H23N5O2/c1-31-14-10-22(30)27-16-7-8-17-18(9-12-26-20(17)15-16)23-21-6-4-13-29(21)28-24(23)19-5-2-3-11-25-19/h2-3,5,7-9,11-12,15H,4,6,10,13-14H2,1H3,(H,27,30)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of TGFR1				Eur J Med Chem 44: 4259-65 (2009) Article DOI: 10.1016/j.ejmech.2009.07.008 BindingDB Entry DOI: 10.7270/Q2BC3ZM9
					More data for this Ligand-Target Pair