BDBM50301174 CHEMBL584928::methyl 4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-ylcarbamate

SMILES: COC(=O)Nc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1

InChI Key: InChIKey=HTVQKYMLRXMMGS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50301174   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50301174 (CHEMBL584928 | methyl 4-(2-(pyridin-2-yl)-5,6-dihy...) Show SMILES COC(=O)Nc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1 |(-8.63,-32.71,;-7.28,-33.46,;-5.96,-32.66,;-5.99,-31.12,;-4.61,-33.41,;-3.29,-32.61,;-3.31,-31.07,;-2,-30.29,;-.66,-31.03,;.66,-30.24,;2.01,-30.98,;2.04,-32.52,;.71,-33.32,;-.64,-32.57,;-1.95,-33.35,;.64,-28.7,;-.63,-27.81,;-2.17,-27.83,;-2.66,-26.37,;-1.43,-25.45,;-.17,-26.34,;1.37,-26.31,;1.87,-27.77,;3.2,-28.53,;3.21,-30.08,;4.55,-30.84,;5.88,-30.06,;5.87,-28.51,;4.53,-27.75,)| Show InChI InChI=1S/C22H19N5O2/c1-29-22(28)25-14-7-8-15-16(9-11-24-18(15)13-14)20-19-6-4-12-27(19)26-21(20)17-5-2-3-10-23-17/h2-3,5,7-11,13H,4,6,12H2,1H3,(H,25,28)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of TGFR1				Eur J Med Chem 44: 4259-65 (2009) Article DOI: 10.1016/j.ejmech.2009.07.008 BindingDB Entry DOI: 10.7270/Q2BC3ZM9
					More data for this Ligand-Target Pair